COG1

Entrez Summary: The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008].
UniProt Summary: Required for normal Golgi function. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 18/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	1/20
lung	3/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Golgi transport complex
intra-Golgi vesicle-mediated transport
trans-Golgi network membrane
Golgi organization
endoplasmic reticulum to Golgi vesicle-mediated transport
Golgi vesicle transport
endomembrane system organization
Golgi membrane
Golgi apparatus
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport