COIL

Entrez Summary: N/A
UniProt Summary: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mitomycin-C 0.06μM R08 exp503	-1.74
Nifurtimox 1μM R03 exp141	2.09

U2 snRNA binding
U1 snRNA binding
spliceosomal snRNP assembly
Cajal body
fibrillar center
protein C-terminus binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
nuclear body
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
nucleolus
RNA processing
identical protein binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
membrane
gene expression