COL11A1 [The Human Chemical-Genetic Interaction Map Project]

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======= COL11A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL11A1
  * **<color #00a2e8>Official Name</color>**: collagen type XI alpha 1 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1301|1301]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12107|P12107]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL11A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL11A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
|COLFI|
|Laminin G 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen type XI trimer|
|heparan sulfate binding|
|tendon development|
|detection of mechanical stimulus involved in sensory perception of sound|
|cartilage condensation|
|cell aggregation|
|extracellular matrix binding|
|detection of mechanical stimulus involved in sensory perception|
|extracellular matrix structural constituent conferring tensile strength|
|endodermal cell differentiation|
|chondrocyte development|
|detection of mechanical stimulus|
|collagen fibril organization|
|endoderm formation|
|ventricular cardiac muscle tissue morphogenesis|
|ventricular cardiac muscle tissue development|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|endoderm development|
|protein binding, bridging|
|muscle tissue morphogenesis|
|chondrocyte differentiation|
|muscle organ morphogenesis|
|proteoglycan metabolic process|
|embryonic skeletal system morphogenesis|
|inner ear morphogenesis|
|formation of primary germ layer|
|ear morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|embryonic skeletal system development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|extracellular matrix structural constituent|
|sensory perception of sound|
|gastrulation|
|cardiac muscle tissue development|
|sensory perception of mechanical stimulus|
|heparin binding|
|cardiac chamber development|
|cartilage development|
|inner ear development|
|response to mechanical stimulus|
|ear development|
|visual perception|
|connective tissue development|
|sensory perception of light stimulus|
|extracellular matrix|
|skeletal system morphogenesis|
|heart morphogenesis|
|sensory organ morphogenesis|
|ossification|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|endoplasmic reticulum lumen|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|glycoprotein metabolic process|
|extracellular structure organization|
|embryonic organ development|
|supramolecular fiber organization|
|muscle structure development|
|skeletal system development|
|heart development|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|detection of stimulus|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|carbohydrate derivative metabolic process|
|response to abiotic stimulus|
|nervous system process|
|extracellular space|
|cell development|
|tissue development|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|1.7|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.76|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.8|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.92|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL11A1 Expression in NALM6 Cells: -4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>