COL11A1

Entrez Summary: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen type XI trimer
heparan sulfate binding
tendon development
detection of mechanical stimulus involved in sensory perception of sound
cartilage condensation
cell aggregation
extracellular matrix binding
detection of mechanical stimulus involved in sensory perception
extracellular matrix structural constituent conferring tensile strength
endodermal cell differentiation
chondrocyte development
detection of mechanical stimulus
collagen fibril organization
endoderm formation
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue development
cardiac muscle tissue morphogenesis
cardiac ventricle morphogenesis
endoderm development
protein binding, bridging
muscle tissue morphogenesis
chondrocyte differentiation
muscle organ morphogenesis
proteoglycan metabolic process
embryonic skeletal system morphogenesis
inner ear morphogenesis
formation of primary germ layer
ear morphogenesis
detection of external stimulus
detection of abiotic stimulus
embryonic skeletal system development
cardiac chamber morphogenesis
cardiac ventricle development
extracellular matrix structural constituent
sensory perception of sound
gastrulation
cardiac muscle tissue development
sensory perception of mechanical stimulus
heparin binding
cardiac chamber development