COL12A1

Entrez Summary: This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen type XII trimer
growth plate cartilage chondrocyte morphogenesis
chondrocyte morphogenesis involved in endochondral bone morphogenesis
chondrocyte morphogenesis
growth plate cartilage morphogenesis
growth plate cartilage chondrocyte differentiation
chondrocyte development involved in endochondral bone morphogenesis
cartilage morphogenesis
chondrocyte differentiation involved in endochondral bone morphogenesis
growth plate cartilage development
extracellular matrix structural constituent conferring tensile strength
endodermal cell differentiation
endochondral bone growth
chondrocyte development
cartilage development involved in endochondral bone morphogenesis
bone growth
collagen fibril organization
endoderm formation
extracellular vesicle
endochondral bone morphogenesis
endoderm development
chondrocyte differentiation
organ growth
formation of primary germ layer
bone morphogenesis
gastrulation
cartilage development
bone development
connective tissue development
extracellular matrix
skeletal system morphogenesis
endoplasmic reticulum lumen
extracellular matrix organization
collagen-containing extracellular matrix
extracellular structure organization
developmental growth
growth
supramolecular fiber organization
skeletal system development
cell morphogenesis involved in differentiation