COL8A1

Entrez Summary: N/A
UniProt Summary: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. {ECO:0000269|PubMed:11708810}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Collagen
C1q

collagen type VIII trimer
endodermal cell differentiation
extracellular matrix structural constituent conferring tensile strength
endoderm formation
endoderm development
epithelial cell proliferation
formation of primary germ layer
camera-type eye morphogenesis
positive regulation of cell-substrate adhesion
extracellular matrix structural constituent
eye morphogenesis
gastrulation
regulation of cell-substrate adhesion
extracellular matrix
sensory organ morphogenesis
endoplasmic reticulum lumen
camera-type eye development
angiogenesis
extracellular matrix organization
eye development
visual system development
collagen-containing extracellular matrix
sensory system development
extracellular structure organization
positive regulation of cell adhesion
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
sensory organ development
cell population proliferation
embryonic morphogenesis
tube morphogenesis
regulation of cell adhesion
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
cell adhesion
biological adhesion
animal organ morphogenesis