COL8A2

Entrez Summary: This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Deferoxamine 11μM R07 exp350	-1.76
ABT-702 5μM R07 exp318	-1.73

C1q
Collagen

extracellular matrix structural constituent conferring tensile strength
collagen trimer
protein binding, bridging
epithelial cell proliferation
basement membrane
camera-type eye morphogenesis
extracellular matrix structural constituent
eye morphogenesis
extracellular matrix
sensory organ morphogenesis
endoplasmic reticulum lumen
camera-type eye development
angiogenesis
extracellular matrix organization
eye development
visual system development
collagen-containing extracellular matrix
sensory system development
extracellular structure organization
blood vessel morphogenesis
blood vessel development
cell-cell adhesion
vasculature development
cardiovascular system development
sensory organ development
cell population proliferation
tube morphogenesis
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
cell adhesion
biological adhesion
animal organ morphogenesis
extracellular space
extracellular region