COMMD1

Gene Information

Official Symbol: COMMD1
Official Name: copper metabolism domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 150684
UniProt: Q8N668
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). {ECO:0000269|PubMed:14645214, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:17183367, ECO:0000269|PubMed:17309234, ECO:0000269|PubMed:20048074, ECO:0000269|PubMed:20237237, ECO:0000269|PubMed:20458141, ECO:0000269|PubMed:20595380, ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370, ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:23515529, ECO:0000269|PubMed:25355947}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13450
Expression level (log2 read counts): 6.58

Expression Distribution

plasma membrane to endosome transport
negative regulation of sodium ion transmembrane transport
negative regulation of protein localization to cell surface
Cul2-RING ubiquitin ligase complex
copper ion homeostasis
negative regulation of sodium ion transport
phosphatidic acid binding
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
regulation of protein localization to cell surface
phosphatidylinositol-3,4,5-trisphosphate binding
copper ion binding
Golgi to plasma membrane transport
regulation of sodium ion transmembrane transport
phosphatidylinositol-4,5-bisphosphate binding
negative regulation of cation transmembrane transport
negative regulation of NF-kappaB transcription factor activity
regulation of sodium ion transport
vesicle-mediated transport to the plasma membrane
negative regulation of ion transmembrane transport
post-Golgi vesicle-mediated transport
negative regulation of cellular protein localization
positive regulation of protein ubiquitination
recycling endosome
negative regulation of transmembrane transport
regulation of proteasomal ubiquitin-dependent protein catabolic process
transition metal ion homeostasis
positive regulation of protein modification by small protein conjugation or removal
negative regulation of ion transport
regulation of ubiquitin-dependent protein catabolic process
negative regulation of DNA-binding transcription factor activity
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
endosome membrane
regulation of proteolysis involved in cellular protein catabolic process
regulation of protein modification by small protein conjugation or removal
regulation of cellular protein catabolic process
early endosome
endosome
regulation of cation transmembrane transport