COPS8 [The Human Chemical-Genetic Interaction Map Project]

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======= COPS8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPS8
  * **<color #00a2e8>Official Name</color>**: COP9 signalosome subunit 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10920|10920]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99627|Q99627]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPS8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPS8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616011|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI Csn8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COP9 signalosome assembly|
|protein deneddylation|
|activation of NF-kappaB-inducing kinase activity|
|nucleotide-excision repair, DNA damage recognition|
|COP9 signalosome|
|transcription-coupled nucleotide-excision repair|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|regulation of NIK/NF-kappaB signaling|
|nucleotide-excision repair|
|protein modification by small protein removal|
|activation of protein kinase activity|
|post-translational protein modification|
|DNA repair|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chromosome organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|proteolysis|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.72|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.21|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cops7b|COPS7B]]|0.597|
|[[:human genes:e:eno1|ENO1]]|0.45|
|[[:human genes:r:rpe|RPE]]|0.425|
|[[:human genes:c:cops4|COPS4]]|0.421|
|[[:human genes:r:rptor|RPTOR]]|0.41|
|[[:human genes:t:tgs1|TGS1]]|0.408|
|[[:human genes:r:rnmt|RNMT]]|0.404|
|[[:human genes:p:pmm2|PMM2]]|0.401|
|[[:human genes:m:meaf6|MEAF6]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 455/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|15/28|
|bone|9/26|
|breast|27/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|14/21|
|liver|13/20|
|lung|55/75|
|lymphocyte|6/16|
|ovary|21/26|
|pancreas|17/24|
|peripheral nervous system|10/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|18/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPS8 Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>