COPS8

Entrez Summary: N/A
UniProt Summary: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 455/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	16/28
blood	15/28
bone	9/26
breast	27/33
central nervous system	33/56
cervix	3/4
colorectal	11/17
esophagus	6/13
fibroblast	1/1
gastric	8/16
kidney	14/21
liver	13/20
lung	55/75
lymphocyte	6/16
ovary	21/26
pancreas	17/24
peripheral nervous system	10/16
plasma cell	10/15
prostate	1/1
skin	16/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	18/29
uterus	2/5

Expression Distribution

COP9 signalosome assembly
protein deneddylation
activation of NF-kappaB-inducing kinase activity
nucleotide-excision repair, DNA damage recognition
COP9 signalosome
transcription-coupled nucleotide-excision repair
positive regulation of NIK/NF-kappaB signaling
NIK/NF-kappaB signaling
regulation of NIK/NF-kappaB signaling
nucleotide-excision repair
protein modification by small protein removal
activation of protein kinase activity
post-translational protein modification
DNA repair
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
negative regulation of cell population proliferation
perinuclear region of cytoplasm
DNA metabolic process
cellular response to DNA damage stimulus
regulation of protein kinase activity
cellular protein-containing complex assembly
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
protein modification by small protein conjugation or removal
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
chromosome organization
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
proteolysis
phosphorylation
positive regulation of catalytic activity
regulation of protein phosphorylation
protein-containing complex assembly
regulation of phosphorylation