COQ7 [The Human Chemical-Genetic Interaction Map Project]

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======= COQ7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ7
  * **<color #00a2e8>Official Name</color>**: coenzyme Q7, hydroxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10229|10229]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99807|Q99807]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601683|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. {ECO:0000255|HAMAP-Rule:MF_03194}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COQ7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|
|extrinsic component of mitochondrial inner membrane|
|ubiquinone biosynthetic process|
|quinone biosynthetic process|
|ubiquinone metabolic process|
|determination of adult lifespan|
|ketone biosynthetic process|
|quinone metabolic process|
|multicellular organism aging|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|coenzyme biosynthetic process|
|regulation of reactive oxygen species metabolic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|aging|
|mitochondrial inner membrane|
|cofactor metabolic process|
|small molecule biosynthetic process|
|oxidation-reduction process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.81|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.82|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.08|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.2|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.28|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.34|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.35|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.63|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.51|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.569|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.549|
|[[:human genes:n:ndufa2|NDUFA2]]|0.547|
|[[:human genes:n:ndufb11|NDUFB11]]|0.544|
|[[:human genes:a:acad9|ACAD9]]|0.542|
|[[:human genes:g:grsf1|GRSF1]]|0.539|
|[[:human genes:n:ndufc2|NDUFC2]]|0.537|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.535|
|[[:human genes:m:mrpl21|MRPL21]]|0.528|
|[[:human genes:n:ndufs2|NDUFS2]]|0.524|
|[[:human genes:f:fastkd2|FASTKD2]]|0.521|
|[[:human genes:n:ndufa1|NDUFA1]]|0.52|
|[[:human genes:n:ndufa11|NDUFA11]]|0.519|
|[[:human genes:n:ndufb5|NDUFB5]]|0.515|
|[[:human genes:c:coq2|COQ2]]|0.515|
|[[:human genes:f:foxred1|FOXRED1]]|0.514|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.512|
|[[:human genes:n:ndufb9|NDUFB9]]|0.511|
|[[:human genes:c:coq3|COQ3]]|0.511|
|[[:human genes:l:lars2|LARS2]]|0.509|
|[[:human genes:m:mto1|MTO1]]|0.509|
|[[:human genes:n:nars2|NARS2]]|0.505|
|[[:human genes:g:gfm1|GFM1]]|0.505|
|[[:human genes:m:mrps21|MRPS21]]|0.5|
|[[:human genes:e:ears2|EARS2]]|0.5|
|[[:human genes:n:nubpl|NUBPL]]|0.498|
|[[:human genes:g:gfm2|GFM2]]|0.491|
|[[:human genes:c:chchd1|CHCHD1]]|0.49|
|[[:human genes:p:pdss1|PDSS1]]|0.487|
|[[:human genes:y:yars2|YARS2]]|0.486|
|[[:human genes:s:sco2|SCO2]]|0.485|
|[[:human genes:c:c12orf65|C12orf65]]|0.484|
|[[:human genes:n:ndufb7|NDUFB7]]|0.484|
|[[:human genes:m:mrpl53|MRPL53]]|0.482|
|[[:human genes:n:ndufa3|NDUFA3]]|0.482|
|[[:human genes:n:ndufs7|NDUFS7]]|0.48|
|[[:human genes:i:iba57|IBA57]]|0.48|
|[[:human genes:m:mettl17|METTL17]]|0.475|
|[[:human genes:b:bcs1l|BCS1L]]|0.471|
|[[:human genes:s:selrc1|SELRC1]]|0.469|
|[[:human genes:m:mrpl23|MRPL23]]|0.469|
|[[:human genes:m:mrps5|MRPS5]]|0.464|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.461|
|[[:human genes:r:rbfa|RBFA]]|0.461|
|[[:human genes:c:coq6|COQ6]]|0.461|
|[[:human genes:f:fastkd5|FASTKD5]]|0.46|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.46|
|[[:human genes:q:qrsl1|QRSL1]]|0.46|
|[[:human genes:m:mrp63|MRP63]]|0.459|
|[[:human genes:p:pet112|PET112]]|0.458|
|[[:human genes:g:gatc|GATC]]|0.458|
|[[:human genes:m:mrpl3|MRPL3]]|0.457|
|[[:human genes:m:mrpl44|MRPL44]]|0.456|
|[[:human genes:p:pars2|PARS2]]|0.456|
|[[:human genes:m:mrpl15|MRPL15]]|0.454|
|[[:human genes:m:mrps34|MRPS34]]|0.453|
|[[:human genes:h:hars2|HARS2]]|0.453|
|[[:human genes:s:sfxn4|SFXN4]]|0.452|
|[[:human genes:d:dap3|DAP3]]|0.452|
|[[:human genes:r:rpusd4|RPUSD4]]|0.451|
|[[:human genes:m:mrpl43|MRPL43]]|0.451|
|[[:human genes:m:mtg1|MTG1]]|0.447|
|[[:human genes:m:mrps6|MRPS6]]|0.446|
|[[:human genes:m:mrps14|MRPS14]]|0.444|
|[[:human genes:n:ndufb3|NDUFB3]]|0.444|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.443|
|[[:human genes:m:mtif2|MTIF2]]|0.443|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.44|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.439|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.439|
|[[:human genes:m:mrpl12|MRPL12]]|0.438|
|[[:human genes:c:c17orf89|C17orf89]]|0.438|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.437|
|[[:human genes:n:ndufs5|NDUFS5]]|0.436|
|[[:human genes:m:mterfd1|MTERFD1]]|0.436|
|[[:human genes:t:tefm|TEFM]]|0.435|
|[[:human genes:i:ict1|ICT1]]|0.435|
|[[:human genes:m:mrps35|MRPS35]]|0.433|
|[[:human genes:c:coq4|COQ4]]|0.433|
|[[:human genes:s:sars2|SARS2]]|0.431|
|[[:human genes:m:mcat|MCAT]]|0.431|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.429|
|[[:human genes:p:pet117|PET117]]|0.428|
|[[:human genes:n:ndufs8|NDUFS8]]|0.427|
|[[:human genes:t:tars2|TARS2]]|0.427|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.426|
|[[:human genes:f:ftsj2|FTSJ2]]|0.425|
|[[:human genes:m:mtg2|MTG2]]|0.424|
|[[:human genes:n:ndufv1|NDUFV1]]|0.424|
|[[:human genes:n:ndufa10|NDUFA10]]|0.422|
|[[:human genes:m:mrps10|MRPS10]]|0.421|
|[[:human genes:n:ndufs1|NDUFS1]]|0.421|
|[[:human genes:v:vars2|VARS2]]|0.421|
|[[:human genes:m:mrpl47|MRPL47]]|0.42|
|[[:human genes:n:ndufa8|NDUFA8]]|0.42|
|[[:human genes:r:rars2|RARS2]]|0.417|
|[[:human genes:w:wars2|WARS2]]|0.417|
|[[:human genes:a:atp5sl|ATP5SL]]|0.413|
|[[:human genes:t:tufm|TUFM]]|0.412|
|[[:human genes:d:ddx28|DDX28]]|0.41|
|[[:human genes:n:ndufc1|NDUFC1]]|0.41|
|[[:human genes:c:cox15|COX15]]|0.407|
|[[:human genes:w:wbscr16|WBSCR16]]|0.407|
|[[:human genes:a:aars2|AARS2]]|0.407|
|[[:human genes:n:ndufb4|NDUFB4]]|0.405|
|[[:human genes:n:ndufb2|NDUFB2]]|0.403|
|[[:human genes:r:rpusd3|RPUSD3]]|0.402|
|[[:human genes:u:uqcr10|UQCR10]]|0.401|
|[[:human genes:m:mrpl45|MRPL45]]|0.401|
|[[:human genes:c:coa6|COA6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1947
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ7 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>