COQ7

Entrez Summary: The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010].
UniProt Summary: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. {ECO:0000255|HAMAP-Rule:MF_03194}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubacin 1.6μM R07 exp416	1.79
GSK-J4 1.5μM R08 exp441	1.81
PU-H71 1μM R08 exp515	1.81
Aphidicolin 0.4μM R08 exp440	1.82
Amiloride 100μM R08 exp447	2
Rotenone 0.07μM R08 exp431	2.08
Trientine 500μM R08 exp534	2.2
MK2206 4μM R08 exp504	2.28
Vemurafenib 6.6μM R08 exp434	2.34
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	2.35
Thimerosal 0.85μM R08 exp529	2.63
Ammonium tetrathiomolybdate 10μM R08 exp448	3.51
HMS-I2 10μM R06 exp288	3.93

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
extrinsic component of mitochondrial inner membrane
ubiquinone biosynthetic process
quinone biosynthetic process
ubiquinone metabolic process
determination of adult lifespan
ketone biosynthetic process
quinone metabolic process
multicellular organism aging
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
coenzyme biosynthetic process
regulation of reactive oxygen species metabolic process
cofactor biosynthetic process
coenzyme metabolic process
aging
mitochondrial inner membrane
cofactor metabolic process
small molecule biosynthetic process
oxidation-reduction process
small molecule metabolic process