CORO1B [The Human Chemical-Genetic Interaction Map Project]

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======= CORO1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CORO1B
  * **<color #00a2e8>Official Name</color>**: coronin 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57175|57175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BR76|Q9BR76]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CORO1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CORO1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1899|
|DUF1900|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to cell leading edge|
|actin filament branching|
|negative regulation of smooth muscle cell chemotaxis|
|negative regulation of Arp2/3 complex-mediated actin nucleation|
|positive regulation of lamellipodium morphogenesis|
|regulation of smooth muscle cell chemotaxis|
|endothelial cell chemotaxis|
|negative regulation of actin nucleation|
|Arp2/3 complex binding|
|regulation of lamellipodium morphogenesis|
|regulation of Arp2/3 complex-mediated actin nucleation|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|negative regulation of smooth muscle cell migration|
|ruffle organization|
|regulation of actin nucleation|
|positive regulation of lamellipodium organization|
|cell periphery|
|cell leading edge|
|regulation of lamellipodium organization|
|negative regulation of chemotaxis|
|regulation of smooth muscle cell migration|
|actin filament bundle assembly|
|endothelial cell migration|
|actin filament bundle organization|
|stress fiber|
|actin filament|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|regulation of actin filament polymerization|
|ameboidal-type cell migration|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|actin filament binding|
|cell chemotaxis|
|regulation of chemotaxis|
|regulation of protein polymerization|
|actin filament organization|
|negative regulation of cell migration|
|regulation of actin filament organization|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of response to external stimulus|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|focal adhesion|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|wound healing|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|regulation of anatomical structure size|
|response to growth factor|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|actin filament-based process|
|response to wounding|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7063
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CORO1B Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>