CORO1B
Gene Information
- Official Symbol: CORO1B
- Official Name: coronin 1B
- Aliases and Previous Symbols: N/A
- Entrez ID: 57175
- UniProt: Q9BR76
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}.
Pfam Domains GO Terms
Pfam Domains
| DUF1899 |
| DUF1900 |
| WD40 |
GO Terms
| protein localization to cell leading edge |
| actin filament branching |
| negative regulation of smooth muscle cell chemotaxis |
| negative regulation of Arp2/3 complex-mediated actin nucleation |
| positive regulation of lamellipodium morphogenesis |
| regulation of smooth muscle cell chemotaxis |
| endothelial cell chemotaxis |
| negative regulation of actin nucleation |
| Arp2/3 complex binding |
| regulation of lamellipodium morphogenesis |
| regulation of Arp2/3 complex-mediated actin nucleation |
| cellular response to platelet-derived growth factor stimulus |
| response to platelet-derived growth factor |
| negative regulation of smooth muscle cell migration |
| ruffle organization |
| regulation of actin nucleation |
| positive regulation of lamellipodium organization |
| cell periphery |
| cell leading edge |
| regulation of lamellipodium organization |
| negative regulation of chemotaxis |
| regulation of smooth muscle cell migration |
| actin filament bundle assembly |
| endothelial cell migration |
| actin filament bundle organization |
| stress fiber |
| actin filament |
| epithelial cell migration |
| epithelium migration |
| tissue migration |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| regulation of actin filament polymerization |
| ameboidal-type cell migration |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| actin filament binding |
| cell chemotaxis |
| regulation of chemotaxis |
| regulation of protein polymerization |
| actin filament organization |
| negative regulation of cell migration |
| regulation of actin filament organization |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| cadherin binding |
| negative regulation of locomotion |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of response to external stimulus |
| negative regulation of organelle organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| focal adhesion |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| wound healing |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| regulation of anatomical structure size |
| response to growth factor |
| regulation of cytoskeleton organization |
| chemotaxis |
| taxis |
| actin filament-based process |
| response to wounding |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| regulation of cell migration |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| cellular protein localization |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Alda-1 10μM R06 exp262 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7063
- Expression level (log2 read counts): 5.95
Expression Distribution
CORO1B Expression in NALM6 Cells: 5.95
