CORO2B

Entrez Summary: N/A
UniProt Summary: May play a role in the reorganization of neuronal actin structure.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Metformin 40μM R03 exp132	-2.08
Mubritinib 0.2μM R01 exp48	-1.7

talin binding
regulation of glomerular filtration
vinculin binding
renal system process involved in regulation of blood volume
negative regulation of stress fiber assembly
negative regulation of actin filament bundle assembly
renal system process involved in regulation of systemic arterial blood pressure
cell-substrate adherens junction assembly
focal adhesion assembly
regulation of renal system process
adherens junction assembly
cell-substrate junction assembly
negative regulation of cell-substrate adhesion
regulation of stress fiber assembly
adherens junction organization
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
regulation of systemic arterial blood pressure
renal system process
cell-matrix adhesion
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
cell junction assembly
regulation of blood pressure
cell-substrate adhesion
negative regulation of establishment of protein localization
actin filament binding
regulation of cell-substrate adhesion
cell junction organization
actin cytoskeleton
regulation of actin filament organization
actin binding
negative regulation of cell adhesion
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of actin filament-based process
blood circulation
circulatory system process
focal adhesion