COX15 [The Human Chemical-Genetic Interaction Map Project]

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======= COX15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX15
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly homolog COX15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1355|1355]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7KZN9|Q7KZN9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603646|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the biosynthesis of heme A. {ECO:0000269|PubMed:12474143}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX15-CtaA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heme a biosynthetic process|
|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|
|oxidoreductase activity, acting on the CH-CH group of donors|
|heme a metabolic process|
|cytochrome complex|
|mitochondrial respirasome|
|mitochondrial electron transport, cytochrome c to oxygen|
|aerobic electron transport chain|
|heme biosynthetic process|
|respiratory chain complex IV assembly|
|porphyrin-containing compound biosynthetic process|
|cytochrome-c oxidase activity|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|cytochrome complex assembly|
|porphyrin-containing compound metabolic process|
|respiratory gaseous exchange by respiratory system|
|molecular adaptor activity|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|heme binding|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|cofactor biosynthetic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|cellular protein-containing complex assembly|
|ion transmembrane transport|
|oxidation-reduction process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.19|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.04|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.99|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.75|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.74|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.72|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.75|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.92|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.93|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.02|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.12|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.25|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.29|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.42|
|[[:results:exp539|42°C R08 exp539]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.637|
|[[:human genes:s:sco2|SCO2]]|0.623|
|[[:human genes:m:mrps6|MRPS6]]|0.612|
|[[:human genes:v:vars2|VARS2]]|0.606|
|[[:human genes:f:fastkd5|FASTKD5]]|0.601|
|[[:human genes:n:nars2|NARS2]]|0.598|
|[[:human genes:g:gfm1|GFM1]]|0.595|
|[[:human genes:c:coa6|COA6]]|0.591|
|[[:human genes:y:yars2|YARS2]]|0.591|
|[[:human genes:m:mrps21|MRPS21]]|0.581|
|[[:human genes:c:coa3|COA3]]|0.567|
|[[:human genes:d:dap3|DAP3]]|0.563|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.562|
|[[:human genes:m:mrpl21|MRPL21]]|0.558|
|[[:human genes:t:tars2|TARS2]]|0.556|
|[[:human genes:b:bcs1l|BCS1L]]|0.556|
|[[:human genes:e:ears2|EARS2]]|0.549|
|[[:human genes:m:mrps26|MRPS26]]|0.546|
|[[:human genes:r:rpusd4|RPUSD4]]|0.546|
|[[:human genes:p:pet117|PET117]]|0.544|
|[[:human genes:r:rars2|RARS2]]|0.543|
|[[:human genes:p:pet112|PET112]]|0.541|
|[[:human genes:l:lars2|LARS2]]|0.537|
|[[:human genes:q:qrsl1|QRSL1]]|0.536|
|[[:human genes:c:c12orf65|C12orf65]]|0.532|
|[[:human genes:m:mrpl47|MRPL47]]|0.53|
|[[:human genes:c:cox16|COX16]]|0.527|
|[[:human genes:p:pars2|PARS2]]|0.525|
|[[:human genes:m:mrps16|MRPS16]]|0.524|
|[[:human genes:s:sars2|SARS2]]|0.521|
|[[:human genes:d:dars2|DARS2]]|0.521|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.52|
|[[:human genes:m:mrpl23|MRPL23]]|0.52|
|[[:human genes:g:gfm2|GFM2]]|0.515|
|[[:human genes:m:mrps14|MRPS14]]|0.515|
|[[:human genes:m:mrpl53|MRPL53]]|0.513|
|[[:human genes:m:mrps34|MRPS34]]|0.508|
|[[:human genes:c:cox7b|COX7B]]|0.508|
|[[:human genes:c:c10orf2|C10orf2]]|0.505|
|[[:human genes:m:mrps18a|MRPS18A]]|0.503|
|[[:human genes:m:mrpl55|MRPL55]]|0.498|
|[[:human genes:m:mtpap|MTPAP]]|0.493|
|[[:human genes:n:ndufb11|NDUFB11]]|0.489|
|[[:human genes:c:cox11|COX11]]|0.487|
|[[:human genes:m:mrps27|MRPS27]]|0.486|
|[[:human genes:m:mrps5|MRPS5]]|0.483|
|[[:human genes:m:mrp63|MRP63]]|0.483|
|[[:human genes:m:mrps25|MRPS25]]|0.482|
|[[:human genes:c:cox17|COX17]]|0.479|
|[[:human genes:r:rbfa|RBFA]]|0.479|
|[[:human genes:a:aars2|AARS2]]|0.477|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.474|
|[[:human genes:p:pnpt1|PNPT1]]|0.474|
|[[:human genes:t:tefm|TEFM]]|0.471|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.47|
|[[:human genes:n:ndufa3|NDUFA3]]|0.468|
|[[:human genes:l:lrpprc|LRPPRC]]|0.468|
|[[:human genes:f:fars2|FARS2]]|0.468|
|[[:human genes:m:mrpl18|MRPL18]]|0.467|
|[[:human genes:m:mettl17|METTL17]]|0.466|
|[[:human genes:m:mrps11|MRPS11]]|0.466|
|[[:human genes:m:mrpl45|MRPL45]]|0.465|
|[[:human genes:m:mars2|MARS2]]|0.464|
|[[:human genes:a:atp5c1|ATP5C1]]|0.457|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.456|
|[[:human genes:f:ftsj2|FTSJ2]]|0.453|
|[[:human genes:c:cars2|CARS2]]|0.452|
|[[:human genes:m:mrps2|MRPS2]]|0.45|
|[[:human genes:t:trub2|TRUB2]]|0.449|
|[[:human genes:c:cox6c|COX6C]]|0.447|
|[[:human genes:m:mrpl44|MRPL44]]|0.447|
|[[:human genes:w:wars2|WARS2]]|0.445|
|[[:human genes:h:hars2|HARS2]]|0.445|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.443|
|[[:human genes:m:mrpl3|MRPL3]]|0.442|
|[[:human genes:a:atp5a1|ATP5A1]]|0.442|
|[[:human genes:p:polrmt|POLRMT]]|0.442|
|[[:human genes:m:mrps23|MRPS23]]|0.442|
|[[:human genes:c:cox20|COX20]]|0.442|
|[[:human genes:m:mrps12|MRPS12]]|0.441|
|[[:human genes:m:mrpl15|MRPL15]]|0.44|
|[[:human genes:r:rpusd3|RPUSD3]]|0.439|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.436|
|[[:human genes:m:mrps10|MRPS10]]|0.433|
|[[:human genes:m:mrpl20|MRPL20]]|0.432|
|[[:human genes:p:polg|POLG]]|0.432|
|[[:human genes:m:mtg1|MTG1]]|0.43|
|[[:human genes:w:wbscr16|WBSCR16]]|0.43|
|[[:human genes:d:dhrsx|DHRSX]]|0.426|
|[[:human genes:m:mtg2|MTG2]]|0.426|
|[[:human genes:n:ndufa2|NDUFA2]]|0.424|
|[[:human genes:t:tufm|TUFM]]|0.424|
|[[:human genes:p:polg2|POLG2]]|0.424|
|[[:human genes:m:mrps24|MRPS24]]|0.42|
|[[:human genes:c:coq2|COQ2]]|0.417|
|[[:human genes:s:slc25a26|SLC25A26]]|0.417|
|[[:human genes:n:ndufs2|NDUFS2]]|0.417|
|[[:human genes:d:dhx30|DHX30]]|0.416|
|[[:human genes:s:slc25a3|SLC25A3]]|0.415|
|[[:human genes:a:atp5b|ATP5B]]|0.414|
|[[:human genes:t:tomm20|TOMM20]]|0.414|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.413|
|[[:human genes:c:cox6b1|COX6B1]]|0.413|
|[[:human genes:c:clpp|CLPP]]|0.412|
|[[:human genes:u:uqcr10|UQCR10]]|0.412|
|[[:human genes:m:mrps9|MRPS9]]|0.412|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.411|
|[[:human genes:n:ndufc2|NDUFC2]]|0.41|
|[[:human genes:m:mrpl11|MRPL11]]|0.41|
|[[:human genes:a:aifm1|AIFM1]]|0.409|
|[[:human genes:a:atp5d|ATP5D]]|0.408|
|[[:human genes:c:chchd1|CHCHD1]]|0.408|
|[[:human genes:t:tfam|TFAM]]|0.408|
|[[:human genes:c:coq7|COQ7]]|0.407|
|[[:human genes:m:mrpl33|MRPL33]]|0.407|
|[[:human genes:t:tmem242|TMEM242]]|0.406|
|[[:human genes:h:higd2a|HIGD2A]]|0.404|
|[[:human genes:e:elac2|ELAC2]]|0.404|
|[[:human genes:c:coa5|COA5]]|0.402|
|[[:human genes:c:coq4|COQ4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1012
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX15 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>