COX15

Entrez Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008].
UniProt Summary: May be involved in the biosynthesis of heme A. {ECO:0000269|PubMed:12474143}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.19
PFI-2 4μM R05 exp239	-2.04
Nicotinamide 1000μM R03 exp101	-1.99
IU1-47 25μM R04 exp182	-1.75
Menadione 5μM R06 exp292	-1.74
D-Fructose 10000μM R06 exp279	-1.71
Monensin 0.3μM R08 exp507	1.72
Mubritinib 0.2μM R02 exp65	1.75
Dimethyl-Sulfoxide 1pc R03 exp120	1.92
Thimerosal 0.85μM R08 exp529	1.93
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.02
Vemurafenib 6.6μM R08 exp434	2.12
Aminopterin 0.005μM R07 exp335	2.25
Hippuristanol 0.12μM R08 exp488	2.29
Ribavirin 10 to 15μM on day4 R04 exp160	2.42
42°C R08 exp539	2.65

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	1/26
breast	2/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	1/16
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

heme a biosynthetic process
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
oxidoreductase activity, acting on the CH-CH group of donors
heme a metabolic process
cytochrome complex
mitochondrial respirasome
mitochondrial electron transport, cytochrome c to oxygen
aerobic electron transport chain
heme biosynthetic process
respiratory chain complex IV assembly
porphyrin-containing compound biosynthetic process
cytochrome-c oxidase activity
tetrapyrrole biosynthetic process
heme metabolic process
cytochrome complex assembly
porphyrin-containing compound metabolic process
respiratory gaseous exchange by respiratory system
molecular adaptor activity
pigment biosynthetic process
tetrapyrrole metabolic process
pigment metabolic process
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
heme binding
proton transmembrane transport
cellular respiration
electron transport chain
ATP metabolic process
cofactor biosynthetic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
cofactor metabolic process
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport