COX5A [The Human Chemical-Genetic Interaction Map Project]

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======= COX5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX5A
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 5A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9377|9377]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20674|P20674]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603773|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX5A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV|
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|cytochrome-c oxidase activity|
|electron transfer activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|transmembrane transport|
|phosphorylation|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.29|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.1|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.06|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.03|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.03|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.95|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.95|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.92|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.86|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.85|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.84|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.77|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.71|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.77|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.86|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.91|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.92|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.85|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c17orf89|C17orf89]]|0.547|
|[[:human genes:y:yars2|YARS2]]|0.54|
|[[:human genes:c:cox16|COX16]]|0.532|
|[[:human genes:m:mrps5|MRPS5]]|0.526|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.515|
|[[:human genes:m:mrpl23|MRPL23]]|0.489|
|[[:human genes:t:tars2|TARS2]]|0.488|
|[[:human genes:m:mrps2|MRPS2]]|0.488|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.487|
|[[:human genes:m:mrps34|MRPS34]]|0.483|
|[[:human genes:t:tpk1|TPK1]]|0.481|
|[[:human genes:m:mrps14|MRPS14]]|0.48|
|[[:human genes:d:dars2|DARS2]]|0.477|
|[[:human genes:s:sars2|SARS2]]|0.476|
|[[:human genes:m:mrpl53|MRPL53]]|0.474|
|[[:human genes:m:mrpl21|MRPL21]]|0.473|
|[[:human genes:s:selrc1|SELRC1]]|0.473|
|[[:human genes:m:mrps21|MRPS21]]|0.458|
|[[:human genes:m:mrpl11|MRPL11]]|0.456|
|[[:human genes:t:tefm|TEFM]]|0.454|
|[[:human genes:e:ears2|EARS2]]|0.452|
|[[:human genes:c:chchd4|CHCHD4]]|0.449|
|[[:human genes:b:bcs1l|BCS1L]]|0.449|
|[[:human genes:n:ndufb5|NDUFB5]]|0.447|
|[[:human genes:r:rpusd4|RPUSD4]]|0.447|
|[[:human genes:g:gatc|GATC]]|0.445|
|[[:human genes:c:cox6c|COX6C]]|0.444|
|[[:human genes:p:pars2|PARS2]]|0.442|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.442|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.441|
|[[:human genes:m:mrps16|MRPS16]]|0.439|
|[[:human genes:c:c10orf2|C10orf2]]|0.439|
|[[:human genes:e:elac2|ELAC2]]|0.439|
|[[:human genes:h:hars2|HARS2]]|0.438|
|[[:human genes:m:mrps26|MRPS26]]|0.438|
|[[:human genes:f:fars2|FARS2]]|0.438|
|[[:human genes:m:mrps6|MRPS6]]|0.437|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.436|
|[[:human genes:f:fastkd5|FASTKD5]]|0.434|
|[[:human genes:a:atxn10|ATXN10]]|0.434|
|[[:human genes:v:vars2|VARS2]]|0.432|
|[[:human genes:m:mrpl15|MRPL15]]|0.431|
|[[:human genes:n:ndufb11|NDUFB11]]|0.43|
|[[:human genes:d:dap3|DAP3]]|0.43|
|[[:human genes:f:fh|FH]]|0.427|
|[[:human genes:t:thg1l|THG1L]]|0.426|
|[[:human genes:p:polg|POLG]]|0.425|
|[[:human genes:n:ndufa3|NDUFA3]]|0.423|
|[[:human genes:s:slc25a19|SLC25A19]]|0.423|
|[[:human genes:q:qrsl1|QRSL1]]|0.422|
|[[:human genes:m:mrpl20|MRPL20]]|0.421|
|[[:human genes:n:ndufs7|NDUFS7]]|0.42|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.42|
|[[:human genes:s:sco2|SCO2]]|0.419|
|[[:human genes:g:gfm1|GFM1]]|0.418|
|[[:human genes:p:pdss1|PDSS1]]|0.417|
|[[:human genes:c:cox17|COX17]]|0.417|
|[[:human genes:a:adsl|ADSL]]|0.417|
|[[:human genes:r:rars2|RARS2]]|0.416|
|[[:human genes:n:ndufb1|NDUFB1]]|0.416|
|[[:human genes:r:rpia|RPIA]]|0.415|
|[[:human genes:d:dhrsx|DHRSX]]|0.415|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.413|
|[[:human genes:s:slc25a26|SLC25A26]]|0.412|
|[[:human genes:m:mtg2|MTG2]]|0.411|
|[[:human genes:c:c12orf65|C12orf65]]|0.405|
|[[:human genes:t:tmem242|TMEM242]]|0.405|
|[[:human genes:m:mrpl12|MRPL12]]|0.404|
|[[:human genes:w:wbscr16|WBSCR16]]|0.403|
|[[:human genes:a:atp5b|ATP5B]]|0.402|
|[[:human genes:l:lsm10|LSM10]]|0.401|
|[[:human genes:n:nars2|NARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5328
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX5A Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>