COX5A

Entrez Summary: N/A
UniProt Summary: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.29
5-Fluorouracil 2μM R00 exp1	-2.1
Cisplatin 0.35μM R06 exp273	-2.06
BI-2536 0.001μM R01 exp41	-2.03
Epigallocatechin gallate 20μM R05 exp230	-2.03
Cycloheximide 0.02μM R00 exp14	-1.95
Rotenone 20μM R00 exp34	-1.95
A-395N 10μM R05 exp219	-1.92
Daidzin 10μM R06 exp280	-1.86
LJH685 5μM R02 exp73	-1.85
DABN 2μM R00 exp16	-1.84
Rifampicin 1μM R00 exp31	-1.77
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.71
Phenformin 20μM R05 exp212	1.77
iCRT14 30μM R08 exp492	1.86
Deferoxamine 11μM R07 exp350	1.91
Mubritinib 0.2μM R02 exp65	1.92
Atovaquone 15μM R08 exp451	2.85
GSK-J4 1.5μM R08 exp441	3.08

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex IV
aerobic electron transport chain
mitochondrial electron transport, cytochrome c to oxygen
cytochrome-c oxidase activity
electron transfer activity
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
proton transmembrane transport
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
oxidation-reduction process
transmembrane transport
phosphorylation
ion transport