COX6C [The Human Chemical-Genetic Interaction Map Project]

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======= COX6C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX6C
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 6C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1345|1345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09669|P09669]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX6C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX6C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/124090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX6C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|cytochrome-c oxidase activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.77|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.71|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.73|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.8|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.85|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.87|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.93|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.17|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sars2|SARS2]]|0.613|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.584|
|[[:human genes:s:selrc1|SELRC1]]|0.559|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.553|
|[[:human genes:f:fastkd5|FASTKD5]]|0.537|
|[[:human genes:r:rpusd4|RPUSD4]]|0.535|
|[[:human genes:b:bcs1l|BCS1L]]|0.533|
|[[:human genes:m:mrps5|MRPS5]]|0.53|
|[[:human genes:m:mrps21|MRPS21]]|0.529|
|[[:human genes:y:yars2|YARS2]]|0.527|
|[[:human genes:c:cox16|COX16]]|0.524|
|[[:human genes:s:sco2|SCO2]]|0.52|
|[[:human genes:p:pdss1|PDSS1]]|0.52|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.517|
|[[:human genes:m:mrpl55|MRPL55]]|0.517|
|[[:human genes:m:mrps34|MRPS34]]|0.517|
|[[:human genes:m:mrps16|MRPS16]]|0.514|
|[[:human genes:c:cox17|COX17]]|0.514|
|[[:human genes:t:tars2|TARS2]]|0.514|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.513|
|[[:human genes:g:gfm1|GFM1]]|0.51|
|[[:human genes:c:c12orf65|C12orf65]]|0.509|
|[[:human genes:m:mrps9|MRPS9]]|0.509|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.508|
|[[:human genes:m:mrpl15|MRPL15]]|0.508|
|[[:human genes:v:vars2|VARS2]]|0.503|
|[[:human genes:r:rbfa|RBFA]]|0.501|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.501|
|[[:human genes:c:c17orf89|C17orf89]]|0.497|
|[[:human genes:m:mrps18a|MRPS18A]]|0.495|
|[[:human genes:m:mrp63|MRP63]]|0.495|
|[[:human genes:n:ndufa3|NDUFA3]]|0.493|
|[[:human genes:m:mtpap|MTPAP]]|0.493|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.491|
|[[:human genes:d:dars2|DARS2]]|0.489|
|[[:human genes:m:mtg2|MTG2]]|0.488|
|[[:human genes:m:mrpl44|MRPL44]]|0.484|
|[[:human genes:m:mrps24|MRPS24]]|0.483|
|[[:human genes:m:mrpl47|MRPL47]]|0.481|
|[[:human genes:m:mrpl53|MRPL53]]|0.481|
|[[:human genes:m:mrps2|MRPS2]]|0.479|
|[[:human genes:m:mrps25|MRPS25]]|0.478|
|[[:human genes:f:fars2|FARS2]]|0.478|
|[[:human genes:m:mrps14|MRPS14]]|0.477|
|[[:human genes:m:mrps6|MRPS6]]|0.473|
|[[:human genes:m:mrpl21|MRPL21]]|0.472|
|[[:human genes:c:c10orf2|C10orf2]]|0.471|
|[[:human genes:t:tufm|TUFM]]|0.471|
|[[:human genes:m:mrpl23|MRPL23]]|0.47|
|[[:human genes:c:cox7b|COX7B]]|0.469|
|[[:human genes:c:coa6|COA6]]|0.463|
|[[:human genes:s:slc25a26|SLC25A26]]|0.463|
|[[:human genes:q:qrsl1|QRSL1]]|0.463|
|[[:human genes:n:ndufs7|NDUFS7]]|0.461|
|[[:human genes:t:tefm|TEFM]]|0.458|
|[[:human genes:c:coq2|COQ2]]|0.456|
|[[:human genes:w:wbscr16|WBSCR16]]|0.456|
|[[:human genes:m:mrps26|MRPS26]]|0.454|
|[[:human genes:t:tmem126b|TMEM126B]]|0.45|
|[[:human genes:c:cox15|COX15]]|0.447|
|[[:human genes:u:uqcr10|UQCR10]]|0.446|
|[[:human genes:m:mrpl12|MRPL12]]|0.445|
|[[:human genes:m:mtif3|MTIF3]]|0.445|
|[[:human genes:c:chchd4|CHCHD4]]|0.445|
|[[:human genes:c:cox5a|COX5A]]|0.444|
|[[:human genes:d:dhx30|DHX30]]|0.442|
|[[:human genes:n:ndufa2|NDUFA2]]|0.441|
|[[:human genes:m:mrpl34|MRPL34]]|0.441|
|[[:human genes:n:nars2|NARS2]]|0.437|
|[[:human genes:d:dap3|DAP3]]|0.437|
|[[:human genes:m:mrps10|MRPS10]]|0.434|
|[[:human genes:p:pars2|PARS2]]|0.43|
|[[:human genes:n:ndufb11|NDUFB11]]|0.43|
|[[:human genes:r:rars2|RARS2]]|0.427|
|[[:human genes:n:ndufb3|NDUFB3]]|0.423|
|[[:human genes:c:coa5|COA5]]|0.423|
|[[:human genes:p:pet100|PET100]]|0.423|
|[[:human genes:n:ndufb5|NDUFB5]]|0.421|
|[[:human genes:c:coa3|COA3]]|0.421|
|[[:human genes:m:mrps12|MRPS12]]|0.418|
|[[:human genes:c:coq5|COQ5]]|0.417|
|[[:human genes:m:mrps11|MRPS11]]|0.417|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.417|
|[[:human genes:g:gfm2|GFM2]]|0.417|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.414|
|[[:human genes:e:ears2|EARS2]]|0.414|
|[[:human genes:m:mrpl33|MRPL33]]|0.414|
|[[:human genes:e:elac2|ELAC2]]|0.413|
|[[:human genes:t:tpk1|TPK1]]|0.412|
|[[:human genes:t:tomm20|TOMM20]]|0.412|
|[[:human genes:m:mrps22|MRPS22]]|0.411|
|[[:human genes:p:polg2|POLG2]]|0.409|
|[[:human genes:a:angel2|ANGEL2]]|0.409|
|[[:human genes:m:mrps23|MRPS23]]|0.408|
|[[:human genes:t:tfam|TFAM]]|0.407|
|[[:human genes:p:pnpt1|PNPT1]]|0.406|
|[[:human genes:m:mrps33|MRPS33]]|0.406|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.404|
|[[:human genes:m:mterfd2|MTERFD2]]|0.403|
|[[:human genes:t:trub2|TRUB2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|3/20|
|lung|4/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX6C Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>