COX6C

Entrez Summary: N/A
UniProt Summary: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 32/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	1/26
breast	3/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	3/20
lung	4/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

aerobic electron transport chain
mitochondrial electron transport, cytochrome c to oxygen
cytochrome-c oxidase activity
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
proton transmembrane transport
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
oxidation-reduction process
mitochondrion
transmembrane transport
phosphorylation
ion transport