COX8A [The Human Chemical-Genetic Interaction Map Project]

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======= COX8A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX8A
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 8A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1351|1351]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10176|P10176]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX8A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX8A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory chain complex IV|
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|cytochrome-c oxidase activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.05|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.7|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.7|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.71|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.77|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.83|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.92|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.95|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:surf1|SURF1]]|0.546|
|[[:human genes:c:clpx|CLPX]]|0.485|
|[[:human genes:c:cox6a1|COX6A1]]|0.481|
|[[:human genes:m:mrps31|MRPS31]]|0.48|
|[[:human genes:v:vasn|VASN]]|0.476|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.458|
|[[:human genes:c:cmya5|CMYA5]]|0.452|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.437|
|[[:human genes:p:psmd1|PSMD1]]|0.436|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.434|
|[[:human genes:s:snrpa1|SNRPA1]]|0.433|
|[[:human genes:p:plk4|PLK4]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.419|
|[[:human genes:c:c14orf93|C14orf93]]|0.419|
|[[:human genes:c:cope|COPE]]|0.418|
|[[:human genes:m:mt1e|MT1E]]|0.418|
|[[:human genes:t:tfip11|TFIP11]]|0.415|
|[[:human genes:c:cwc22|CWC22]]|0.415|
|[[:human genes:n:nfyb|NFYB]]|0.412|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.41|
|[[:human genes:p:psmd3|PSMD3]]|0.41|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.41|
|[[:human genes:s:supt6h|SUPT6H]]|0.409|
|[[:human genes:i:iscu|ISCU]]|0.409|
|[[:human genes:c:cluh|CLUH]]|0.409|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.409|
|[[:human genes:t:tra2b|TRA2B]]|0.409|
|[[:human genes:m:myo1h|MYO1H]]|0.407|
|[[:human genes:k:krt78|KRT78]]|0.406|
|[[:human genes:z:zfand5|ZFAND5]]|0.406|
|[[:human genes:t:ticrr|TICRR]]|0.406|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.406|
|[[:human genes:a:ankle2|ANKLE2]]|0.405|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.404|
|[[:human genes:s:stil|STIL]]|0.403|
|[[:human genes:c:cdc6|CDC6]]|0.403|
|[[:human genes:f:fbxo5|FBXO5]]|0.403|
|[[:human genes:c:cbwd3|CBWD3]]|0.402|
|[[:human genes:h:hap1|HAP1]]|0.401|
|[[:human genes:a:arcn1|ARCN1]]|0.4|
|[[:human genes:c:ccdc94|CCDC94]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1423
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX8A Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>