COX8A

Entrez Summary: The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008].
UniProt Summary: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.05
LB-100 2μM R05 exp210	1.7
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.7
Nocodazole 0.02μM R00 exp23	1.71
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.77
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.83
Tunicamycin 0.04μM R07 exp418	1.92
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.95
Oligomycin-A 2μM R00 exp25	2.18

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

respiratory chain complex IV
aerobic electron transport chain
mitochondrial electron transport, cytochrome c to oxygen
cytochrome-c oxidase activity
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
proton transmembrane transport
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
oxidation-reduction process
mitochondrion
transmembrane transport
phosphorylation
ion transport