NFYB

Entrez Summary: N/A
UniProt Summary: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 2μM R00 exp1	1.7
Bortezomib 0.005μM R00 exp6	1.75
Bisphenol F 50μM R08 exp457	1.87
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.02
Tubacin 1.6μM R07 exp416	2.47
Oligomycin-A 2μM R00 exp25	2.58

Global Fraction of Cell Lines Where Essential: 129/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	5/28
blood	6/28
bone	6/25
breast	8/33
central nervous system	12/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/15
kidney	2/21
liver	3/20
lung	15/75
lymphocyte	4/14
ovary	6/26
pancreas	2/24
peripheral nervous system	3/16
plasma cell	3/15
prostate	0/1
skin	7/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	1/5

Expression Distribution

Gene	Correlation
NFYC	0.452
COX8A	0.412

Histone
CBFD NFYB HMF

CCAAT-binding factor complex
repressing transcription factor binding
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
protein-DNA complex
regulation of cholesterol metabolic process
RNA polymerase II transcription factor complex
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
RNA polymerase II distal enhancer sequence-specific DNA binding
regulation of steroid metabolic process
regulation of lipid biosynthetic process
transcription regulatory region DNA binding
protein-containing complex binding
regulation of lipid metabolic process
regulation of small molecule metabolic process
protein heterodimerization activity
DNA-binding transcription factor activity
cellular response to cytokine stimulus
response to cytokine
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process