CPB2 [The Human Chemical-Genetic Interaction Map Project]

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======= CPB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPB2
  * **<color #00a2e8>Official Name</color>**: carboxypeptidase B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1361|1361]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96IY4|Q96IY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603101|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:10574983}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M14|
|Propep M14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of extracellular matrix constituent secretion|
|negative regulation of hepatocyte proliferation|
|negative regulation of plasminogen activation|
|regulation of extracellular matrix constituent secretion|
|negative regulation of fibrinolysis|
|regulation of fibrinolysis|
|regulation of hepatocyte proliferation|
|regulation of plasminogen activation|
|positive regulation of extracellular matrix organization|
|fibrinolysis|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|metallocarboxypeptidase activity|
|liver regeneration|
|negative regulation of protein maturation|
|negative regulation of protein processing|
|negative regulation of animal organ morphogenesis|
|regulation of extracellular matrix organization|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|regulation of protein processing|
|regulation of protein maturation|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|negative regulation of wound healing|
|cellular response to monosaccharide stimulus|
|animal organ regeneration|
|regulation of blood coagulation|
|cellular response to carbohydrate stimulus|
|regulation of hemostasis|
|cell|
|regulation of coagulation|
|negative regulation of response to wounding|
|cellular glucose homeostasis|
|response to heat|
|regulation of complement activation|
|negative regulation of epithelial cell proliferation|
|liver development|
|hepaticobiliary system development|
|regulation of humoral immune response|
|response to glucose|
|regulation of wound healing|
|response to hexose|
|response to monosaccharide|
|regeneration|
|regulation of response to wounding|
|response to carbohydrate|
|response to temperature stimulus|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of animal organ morphogenesis|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of epithelial cell proliferation|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of secretion|
|regulation of immune effector process|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|positive regulation of response to external stimulus|
|negative regulation of cell population proliferation|
|regulation of proteolysis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of secretion|
|zinc ion binding|
|cellular homeostasis|
|negative regulation of developmental process|
|positive regulation of transport|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.92|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.71|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15933
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPB2 Expression in NALM6 Cells: 0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>