CPB2

Entrez Summary: N/A
UniProt Summary: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:10574983}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.92
SGC2043 10μM R03 exp152	-1.71
Beta-Estradiol 0.55μM R07 exp425	2.19

Peptidase M14
Propep M14

positive regulation of extracellular matrix constituent secretion
negative regulation of hepatocyte proliferation
negative regulation of plasminogen activation
regulation of extracellular matrix constituent secretion
negative regulation of fibrinolysis
regulation of fibrinolysis
regulation of hepatocyte proliferation
regulation of plasminogen activation
positive regulation of extracellular matrix organization
fibrinolysis
positive regulation of hemostasis
positive regulation of blood coagulation
positive regulation of coagulation
metallocarboxypeptidase activity
liver regeneration
negative regulation of protein maturation
negative regulation of protein processing
negative regulation of animal organ morphogenesis
regulation of extracellular matrix organization
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
positive regulation of wound healing
positive regulation of response to wounding
regulation of protein processing
regulation of protein maturation
cellular response to glucose stimulus
cellular response to hexose stimulus
negative regulation of wound healing
cellular response to monosaccharide stimulus
animal organ regeneration
regulation of blood coagulation
cellular response to carbohydrate stimulus
regulation of hemostasis
cell
regulation of coagulation
negative regulation of response to wounding
cellular glucose homeostasis
response to heat
regulation of complement activation