CPE

Entrez Summary: N/A
UniProt Summary: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

insulin processing
protein localization to secretory granule
insulin metabolic process
neurexin family protein binding
cardiac left ventricle morphogenesis
carboxypeptidase activity
synaptic membrane
metallocarboxypeptidase activity
peptide hormone processing
transport vesicle membrane
cell adhesion molecule binding
peptide hormone secretion
hormone secretion
cardiac ventricle morphogenesis
hormone transport
secretory granule
secretory granule membrane
neuropeptide signaling pathway
cardiac chamber morphogenesis
cardiac ventricle development
protein processing
signal release
cardiac chamber development
peptide secretion
hormone metabolic process
protein maturation
heart morphogenesis
Wnt signaling pathway
cell-cell signaling by wnt
neuronal cell body
cell surface receptor signaling pathway involved in cell-cell signaling
protein localization to membrane
heart development
peptide metabolic process
regulation of hormone levels
protein localization to organelle
cellular amide metabolic process
zinc ion binding
circulatory system development
animal organ morphogenesis