CPLX2

Entrez Summary: N/A
UniProt Summary: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). {ECO:0000250|UniProtKB:P84086, ECO:0000250|UniProtKB:P84088}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
regulation of synaptic vesicle fusion to presynaptic active zone membrane
positive regulation of synaptic plasticity
mast cell activation involved in immune response
mast cell degranulation
mast cell mediated immunity
mast cell granule
mast cell activation
calyx of Held
syntaxin-1 binding
regulation of vesicle fusion
vesicle docking involved in exocytosis
lysosome localization
SNARE complex
terminal bouton
calcium-dependent protein binding
vesicle docking
synaptic vesicle exocytosis
SNARE binding
exocytic process
regulation of synaptic vesicle exocytosis
postsynapse
signal release from synapse
neurotransmitter secretion
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
synaptic vesicle cycle
vesicle-mediated transport in synapse
regulation of neurotransmitter transport
regulation of regulated secretory pathway
signal release
organelle localization by membrane tethering
membrane docking
neurotransmitter transport
regulation of synaptic plasticity
regulation of exocytosis
glutamatergic synapse
regulation of neurotransmitter levels
establishment of organelle localization