CPLX3 [The Human Chemical-Genetic Interaction Map Project]

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======= CPLX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPLX3
  * **<color #00a2e8>Official Name</color>**: complexin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=594855|594855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVH0|Q8WVH0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPLX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPLX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609585|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates a late step in synaptic vesicle exocytosis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaphin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anchored component of presynaptic active zone membrane|
|photoreceptor ribbon synapse|
|neurotransmitter transmembrane transporter activity|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|anchored component of synaptic vesicle membrane|
|regulation of vesicle fusion|
|insulin secretion|
|SNARE complex|
|terminal bouton|
|syntaxin binding|
|peptide hormone secretion|
|synaptic vesicle exocytosis|
|SNARE binding|
|hormone secretion|
|regulation of synaptic vesicle exocytosis|
|hormone transport|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|neurotransmitter transport|
|visual perception|
|regulation of exocytosis|
|sensory perception of light stimulus|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of hormone levels|
|cell junction|
|regulation of vesicle-mediated transport|
|regulated exocytosis|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|sensory perception|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|regulation of organelle organization|
|nervous system process|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.93|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.77|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.404|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.401|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.401|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.4|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPLX3 Expression in NALM6 Cells: -3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>