CPSF7 [The Human Chemical-Genetic Interaction Map Project]

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======= CPSF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPSF7
  * **<color #00a2e8>Official Name</color>**: cleavage and polyadenylation specific factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79869|79869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N684|Q8N684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPSF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPSF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621247|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Binds to cleavage and polyadenylation RNA substrates. {ECO:0000269|PubMed:8626397}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|messenger ribonucleoprotein complex assembly|
|mRNA alternative polyadenylation|
|mRNA cleavage factor complex|
|pre-mRNA cleavage required for polyadenylation|
|mRNA cleavage involved in mRNA processing|
|mRNA cleavage and polyadenylation specificity factor complex|
|regulation of mRNA polyadenylation|
|mRNA cleavage|
|regulation of mRNA 3-end processing|
|protein heterotetramerization|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|protein heterooligomerization|
|RNA 3-end processing|
|regulation of mRNA processing|
|protein tetramerization|
|RNA phosphodiester bond hydrolysis|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|protein complex oligomerization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-3.06|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.82|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.37|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.35|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.25|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.06|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.93|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.93|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.87|
|[[:results:exp539|42°C R08 exp539]]|-1.84|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.83|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.82|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.71|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.7|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.72|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13727
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPSF7 Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>