CPSF7

Entrez Summary: Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016].
UniProt Summary: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Binds to cleavage and polyadenylation RNA substrates. {ECO:0000269|PubMed:8626397}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 2μM R03 exp134	-3.06
Thapsigargin 0.005μM R07 exp407	-2.82
Selumetinib 20μM R02 exp81	-2.75
Bortezomib 0.005μM R00 exp6	-2.37
I-BRD9 4μM R07 exp365	-2.35
Mubritinib 0.2μM R02 exp65	-2.25
Cerivastatin 0.15μM R05 exp226	-2.06
Oligomycin-A 2μM R00 exp25	-1.97
Tubacin 1.6μM R07 exp416	-1.93
UM131593 0.2μM R03 exp106	-1.93
Rapamycin 1μM R00 exp29	-1.87
42°C R08 exp539	-1.84
S-trityl-L-cysteine 0.5μM R05 exp243	-1.83
Cyclosporin-A 0.8μM R07 exp347	-1.82
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.71
Wortmannin 0.5μM R00 exp37	-1.7
Resveratrol 16μM R03 exp147	1.72
Cytochalasin-B 5μM R07 exp349	2.49

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

messenger ribonucleoprotein complex assembly
mRNA alternative polyadenylation
mRNA cleavage factor complex
pre-mRNA cleavage required for polyadenylation
mRNA cleavage involved in mRNA processing
mRNA cleavage and polyadenylation specificity factor complex
regulation of mRNA polyadenylation
mRNA cleavage
regulation of mRNA 3-end processing
protein heterotetramerization
termination of RNA polymerase II transcription
DNA-templated transcription, termination
mRNA 3-end processing
protein heterooligomerization
RNA 3-end processing
regulation of mRNA processing
protein tetramerization
RNA phosphodiester bond hydrolysis
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
nucleic acid phosphodiester bond hydrolysis
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
transcription by RNA polymerase II
protein complex oligomerization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process