CR2 [The Human Chemical-Genetic Interaction Map Project]

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======= CR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CR2
  * **<color #00a2e8>Official Name</color>**: complement C3d receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1380|1380]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20023|P20023]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). {ECO:0000269|PubMed:7753047}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement receptor activity|
|complement binding|
|complement receptor mediated signaling pathway|
|B cell proliferation|
|virus receptor activity|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|viral entry into host cell|
|leukocyte proliferation|
|entry into host|
|entry into host cell|
|B cell differentiation|
|regulation of complement activation|
|transmembrane signaling receptor activity|
|regulation of humoral immune response|
|B cell activation|
|interaction with host|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|viral life cycle|
|receptor complex|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|lymphocyte differentiation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte differentiation|
|humoral immune response|
|lymphocyte activation|
|immune response-activating cell surface receptor signaling pathway|
|regulation of immune effector process|
|immune response-regulating cell surface receptor signaling pathway|
|cell population proliferation|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|immune system development|
|viral process|
|leukocyte mediated immunity|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|protein homodimerization activity|
|leukocyte activation|
|defense response to other organism|
|cell activation|
|immune effector process|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|DNA binding|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CR2 Expression in NALM6 Cells: 0.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>