CR2

Entrez Summary: This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
UniProt Summary: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). {ECO:0000269|PubMed:7753047}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

complement receptor activity
complement binding
complement receptor mediated signaling pathway
B cell proliferation
virus receptor activity
lymphocyte proliferation
mononuclear cell proliferation
viral entry into host cell
leukocyte proliferation
entry into host
entry into host cell
B cell differentiation
regulation of complement activation
transmembrane signaling receptor activity
regulation of humoral immune response
B cell activation
interaction with host
complement activation, classical pathway
humoral immune response mediated by circulating immunoglobulin
complement activation
viral life cycle
receptor complex
immunoglobulin mediated immune response
B cell mediated immunity
lymphocyte differentiation
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
leukocyte differentiation
humoral immune response
lymphocyte activation
immune response-activating cell surface receptor signaling pathway
regulation of immune effector process
immune response-regulating cell surface receptor signaling pathway
cell population proliferation
hemopoiesis
immune response-activating signal transduction
immune response-regulating signaling pathway
hematopoietic or lymphoid organ development
adaptive immune response
activation of immune response