CREB3L4

Entrez Summary: N/A
UniProt Summary: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250, ECO:0000269|PubMed:16236796}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bZIP 1
bZIP 2

cAMP response element binding
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
nuclear membrane
response to endoplasmic reticulum stress
DNA-binding transcription activator activity, RNA polymerase II-specific
spermatogenesis
male gamete generation
Golgi membrane
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
endoplasmic reticulum membrane
Golgi apparatus
multi-organism reproductive process
endoplasmic reticulum
positive regulation of transcription by RNA polymerase II
mitochondrion
reproductive process
reproduction
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process