CREBBP [The Human Chemical-Genetic Interaction Map Project]

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======= CREBBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CREBBP
  * **<color #00a2e8>Official Name</color>**: CREB binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1387|1387]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92793|Q92793]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CREBBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CREBBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:9707565}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-TAZ|
|KIX|
|KAT11|
|Bromodomain|
|DUF902|
|Creb binding|
|ZZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-terminal peptidyl-lysine acetylation|
|MRF binding|
|N-terminal protein amino acid acetylation|
|acetyltransferase activity|
|positive regulation of transcription of Notch receptor target|
|N-terminal protein amino acid modification|
|histone acetyltransferase complex|
|beta-catenin-TCF complex assembly|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|proximal promoter sequence-specific DNA binding|
|protein destabilization|
|histone acetyltransferase activity|
|positive regulation of Notch signaling pathway|
|RNA polymerase II activating transcription factor binding|
|damaged DNA binding|
|embryonic digit morphogenesis|
|RNA polymerase II transcription factor binding|
|p53 binding|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|regulation of smoothened signaling pathway|
|positive regulation of type I interferon production|
|regulation of cellular response to heat|
|cellular response to UV|
|regulation of Notch signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|stimulatory C-type lectin receptor signaling pathway|
|cellular response to light stimulus|
|regulation of transforming growth factor beta receptor signaling pathway|
|histone acetylation|
|regulation of cellular response to transforming growth factor beta stimulus|
|innate immune response activating cell surface receptor signaling pathway|
|internal peptidyl-lysine acetylation|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|Notch signaling pathway|
|regulation of DNA-templated transcription in response to stress|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|regulation of type I interferon production|
|response to UV|
|protein acetylation|
|limb morphogenesis|
|appendage morphogenesis|
|cellular response to radiation|
|transcription initiation from RNA polymerase II promoter|
|limb development|
|appendage development|
|protein acylation|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|DNA-templated transcription, initiation|
|protein maturation|
|regulation of myeloid cell differentiation|
|innate immune response-activating signal transduction|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nuclear chromatin|
|transcription corepressor activity|
|activation of innate immune response|
|regulation of cellular response to growth factor stimulus|
|rhythmic process|
|nuclear body|
|transcription coactivator activity|
|regulation of protein stability|
|response to light stimulus|
|peptidyl-lysine modification|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|transcription factor binding|
|positive regulation of innate immune response|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of response to biotic stimulus|
|histone modification|
|covalent chromatin modification|
|response to oxygen levels|
|chromatin binding|
|regulation of lipid metabolic process|
|response to radiation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|transcription by RNA polymerase II|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|embryonic morphogenesis|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of cytokine production|
|chromatin organization|
|viral process|
|regulation of cellular response to stress|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|embryo development|
|chromosome organization|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-3.07|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-3.03|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.97|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.6|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.44|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.39|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.32|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.29|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.04|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.88|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.88|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.82|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.8|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.74|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.71|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.79|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.8|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.9|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.92|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.92|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.94|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.96|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.98|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.99|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.12|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.14|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.24|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.31|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.37|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.6|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.98|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vezf1|VEZF1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 29/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|2/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3436
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CREBBP Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>