CREBBP

Gene Information

Official Symbol: CREBBP
Official Name: CREB binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 1387
UniProt: Q92793
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
UniProt Summary: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:9707565}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-3.07
MK2206 4μM R08 exp504	-3.03
Dexamethasone 0.006μM R07 exp351	-2.97
AICAR 240μM R05 exp211	-2.6
Wortmannin 5μM R00 exp38	-2.44
TRAIL 50ng/ml R00 exp36	-2.39
Rapamycin 0.001μM R08 exp429	-2.32
All-trans-Retinoic-Acid 8μM R07 exp333	-2.29
I-BRD9 4μM R07 exp365	-2.04
TRAIL 5ng/ml R00 exp35	-1.88
UM0011500 5μM R05 exp245	-1.88
Rapamycin 1μM R00 exp29	-1.82
BI-2536 0.001μM R01 exp41	-1.8
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.74
Tubastatin-A 2.5μM R07 exp417	1.71
Bisphenol A 100μM R06 exp269	1.79
Phenformin 20μM R03 exp143	1.8
LY2090314 0.003μM R08 exp499	1.9
Rucaparib 6.5μM R08 exp520	1.92
UMK57 1μM R01 exp59	1.92
CCT251545 20μM R07 exp326	1.94
Palbociclib 1μM R07 exp382	1.96
UM0129480 7μM R02 exp85	1.98
iCRT14 30μM R08 exp492	1.99
Mubritinib 0.2μM R01 exp48	2.12
LY2090314 0.003μM R08 exp500 no dilution day6	2.14
Amiloride 100μM R08 exp447	2.24
Adefovir 20μM R07 exp332	2.31
FBS-Wisent 0.1 R07 exp426	2.37
THZ531 0.225μM R08 exp444	2.6
Fluvastatin 2.2μM R06 exp282	2.98
Nifuroxazide 5μM R03 exp102	3.27

Global Fraction of Cell Lines Where Essential: 29/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	1/56
cervix	2/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	2/20
lung	1/75
lymphocyte	0/14
ovary	1/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	5/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	1/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3436
Expression level (log2 read counts): 7.29

Expression Distribution

zf-TAZ
KIX
KAT11
Bromodomain
DUF902
Creb binding
ZZ

N-terminal peptidyl-lysine acetylation
MRF binding
N-terminal protein amino acid acetylation
acetyltransferase activity
positive regulation of transcription of Notch receptor target
N-terminal protein amino acid modification
histone acetyltransferase complex
beta-catenin-TCF complex assembly
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cellular response to transforming growth factor beta stimulus
proximal promoter sequence-specific DNA binding
protein destabilization
histone acetyltransferase activity
positive regulation of Notch signaling pathway
RNA polymerase II activating transcription factor binding
damaged DNA binding
embryonic digit morphogenesis
RNA polymerase II transcription factor binding
p53 binding
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of smoothened signaling pathway
positive regulation of type I interferon production
regulation of cellular response to heat
cellular response to UV
regulation of Notch signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
stimulatory C-type lectin receptor signaling pathway
cellular response to light stimulus
regulation of transforming growth factor beta receptor signaling pathway
histone acetylation
regulation of cellular response to transforming growth factor beta stimulus
innate immune response activating cell surface receptor signaling pathway
internal peptidyl-lysine acetylation
regulation of transcription from RNA polymerase II promoter in response to stress
peptidyl-lysine acetylation
internal protein amino acid acetylation
Notch signaling pathway
regulation of DNA-templated transcription in response to stress
embryonic appendage morphogenesis
embryonic limb morphogenesis