CREBL2

Gene Information

Official Symbol: CREBL2
Official Name: cAMP responsive element binding protein like 2
Aliases and Previous Symbols: N/A
Entrez ID: 1389
UniProt: O60519
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor. {ECO:0000269|PubMed:9693048}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18054
Expression level (log2 read counts): 2.89

Expression Distribution

bZIP 1
bZIP 2

positive regulation of glucose import
positive regulation of glucose transmembrane transport
regulation of glucose import
positive regulation of fat cell differentiation
regulation of glucose transmembrane transport
positive regulation of lipid biosynthetic process
positive regulation of peptidyl-serine phosphorylation
regulation of fat cell differentiation
regulation of peptidyl-serine phosphorylation
positive regulation of lipid metabolic process
protein stabilization
regulation of lipid biosynthetic process
positive regulation of transmembrane transport
regulation of protein stability
regulation of lipid metabolic process
regulation of transmembrane transport
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
positive regulation of cell differentiation
positive regulation of transport
positive regulation of protein phosphorylation
positive regulation of phosphorylation
nucleobase-containing compound biosynthetic process
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of protein modification process
organic cyclic compound biosynthetic process
cell cycle
positive regulation of developmental process
regulation of protein phosphorylation
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of phosphorylation
positive regulation of cellular protein metabolic process
cellular nitrogen compound biosynthetic process