CRHBP [The Human Chemical-Genetic Interaction Map Project]

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======= CRHBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRHBP
  * **<color #00a2e8>Official Name</color>**: corticotropin releasing hormone binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1393|1393]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24387|P24387]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRHBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRHBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/122559|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CRF-BP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of corticotropin-releasing hormone receptor activity|
|secondary lysosome|
|regulation of corticotropin-releasing hormone receptor activity|
|negative regulation of corticotropin secretion|
|corticotropin-releasing hormone binding|
|cellular response to cocaine|
|maternal aggressive behavior|
|regulation of corticotropin secretion|
|cellular response to gonadotropin-releasing hormone|
|aggressive behavior|
|varicosity|
|response to gonadotropin-releasing hormone|
|behavioral response to ethanol|
|cellular response to potassium ion|
|dense core granule|
|response to potassium ion|
|cellular response to estrogen stimulus|
|synaptic transmission, dopaminergic|
|multivesicular body|
|cellular response to alkaloid|
|regulation of NMDA receptor activity|
|cellular response to estradiol stimulus|
|regulation of endocrine process|
|negative regulation of peptide hormone secretion|
|peptide binding|
|axon terminus|
|cellular response to cAMP|
|response to cocaine|
|negative regulation of signaling receptor activity|
|negative regulation of hormone secretion|
|regulation of glutamate receptor signaling pathway|
|multi-organism behavior|
|regulation of neurotransmitter receptor activity|
|response to estrogen|
|response to anesthetic|
|cellular response to calcium ion|
|secretory granule|
|response to cAMP|
|response to alkaloid|
|response to ethanol|
|cellular response to ammonium ion|
|perikaryon|
|response to estradiol|
|response to organophosphorus|
|negative regulation of peptide secretion|
|adult behavior|
|response to calcium ion|
|response to purine-containing compound|
|hormone-mediated signaling pathway|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|female pregnancy|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|cellular response to inorganic substance|
|negative regulation of secretion|
|response to alcohol|
|cellular response to tumor necrosis factor|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|response to tumor necrosis factor|
|regulation of transmembrane transporter activity|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|regulation of transporter activity|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|microtubule|
|cellular response to peptide|
|regulation of cation transmembrane transport|
|response to metal ion|
|response to peptide hormone|
|cellular response to drug|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|response to peptide|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|response to toxic substance|
|cellular response to lipid|
|regulation of hormone levels|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of ion transport|
|regulated exocytosis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|Golgi apparatus|
|multi-organism reproductive process|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.93|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.91|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13960
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRHBP Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>