CRHBP
Gene Information
- Official Symbol: CRHBP
- Official Name: corticotropin releasing hormone binding protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 1393
- UniProt: P24387
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Pfam Domains GO Terms
Pfam Domains
| CRF-BP |
GO Terms
| negative regulation of corticotropin-releasing hormone receptor activity |
| secondary lysosome |
| regulation of corticotropin-releasing hormone receptor activity |
| negative regulation of corticotropin secretion |
| corticotropin-releasing hormone binding |
| cellular response to cocaine |
| maternal aggressive behavior |
| regulation of corticotropin secretion |
| cellular response to gonadotropin-releasing hormone |
| aggressive behavior |
| varicosity |
| response to gonadotropin-releasing hormone |
| behavioral response to ethanol |
| cellular response to potassium ion |
| dense core granule |
| response to potassium ion |
| cellular response to estrogen stimulus |
| synaptic transmission, dopaminergic |
| multivesicular body |
| cellular response to alkaloid |
| regulation of NMDA receptor activity |
| cellular response to estradiol stimulus |
| regulation of endocrine process |
| negative regulation of peptide hormone secretion |
| peptide binding |
| axon terminus |
| cellular response to cAMP |
| response to cocaine |
| negative regulation of signaling receptor activity |
| negative regulation of hormone secretion |
| regulation of glutamate receptor signaling pathway |
| multi-organism behavior |
| regulation of neurotransmitter receptor activity |
| response to estrogen |
| response to anesthetic |
| cellular response to calcium ion |
| secretory granule |
| response to cAMP |
| response to alkaloid |
| response to ethanol |
| cellular response to ammonium ion |
| perikaryon |
| response to estradiol |
| response to organophosphorus |
| negative regulation of peptide secretion |
| adult behavior |
| response to calcium ion |
| response to purine-containing compound |
| hormone-mediated signaling pathway |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| female pregnancy |
| response to ammonium ion |
| cellular response to xenobiotic stimulus |
| cellular response to metal ion |
| negative regulation of secretion by cell |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| cellular response to inorganic substance |
| negative regulation of secretion |
| response to alcohol |
| cellular response to tumor necrosis factor |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| response to tumor necrosis factor |
| regulation of transmembrane transporter activity |
| cellular response to peptide hormone stimulus |
| regulation of hormone secretion |
| regulation of transporter activity |
| cognition |
| response to xenobiotic stimulus |
| response to antibiotic |
| microtubule |
| cellular response to peptide |
| regulation of cation transmembrane transport |
| response to metal ion |
| response to peptide hormone |
| cellular response to drug |
| chemical synaptic transmission |
| dendrite |
| anterograde trans-synaptic signaling |
| trans-synaptic signaling |
| synaptic signaling |
| response to peptide |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| regulation of peptide secretion |
| inflammatory response |
| response to toxic substance |
| cellular response to lipid |
| regulation of hormone levels |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| regulation of transmembrane transport |
| behavior |
| regulation of system process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| regulation of ion transport |
| regulated exocytosis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of secretion by cell |
| exocytosis |
| regulation of secretion |
| response to lipid |
| response to hormone |
| response to organic cyclic compound |
| Golgi apparatus |
| multi-organism reproductive process |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| response to drug |
| export from cell |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| response to cytokine |
| cell-cell signaling |
| secretion |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of transport |
| extracellular region |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vincristine 0.0005μM R04 exp190 | -1.93 |
| Wortmannin 5μM R00 exp38 | -1.91 |
| Hydroxyurea 15μM R06 exp289 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13960
- Expression level (log2 read counts): -4.6
Expression Distribution
CRHBP Expression in NALM6 Cells: -4.6
