CRIPT [The Human Chemical-Genetic Interaction Map Project]

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======= CRIPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRIPT
  * **<color #00a2e8>Official Name</color>**: CXXC repeat containing interactor of PDZ3 domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9419|9419]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P021|Q9P021]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRIPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRIPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604594|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. {ECO:0000250|UniProtKB:Q792Q4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cript|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of postsynaptic density protein 95 clustering|
|protein localization to microtubule|
|regulation of postsynaptic membrane organization|
|regulation of postsynaptic density organization|
|protein localization to microtubule cytoskeleton|
|dendritic shaft|
|protein localization to cytoskeleton|
|cytoplasmic microtubule organization|
|scaffold protein binding|
|PDZ domain binding|
|regulation of postsynapse organization|
|fibrillar center|
|dendritic spine|
|regulation of protein localization to membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|microtubule binding|
|postsynaptic density|
|protein-containing complex binding|
|neuronal cell body|
|dendrite|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|regulation of cellular protein localization|
|cell junction|
|microtubule-based process|
|protein localization to organelle|
|nucleolus|
|regulation of cellular localization|
|regulation of protein localization|
|cytoskeleton organization|
|regulation of organelle organization|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.73|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.72|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.74|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.8|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.82|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.86|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRIPT Expression in NALM6 Cells: 3.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>