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Entrez Summary: This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014].
UniProt Summary: Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. {ECO:0000250|UniProtKB:Q792Q4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotine 3000μM R08 exp510	-1.73
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.72
Centrinone 0.5μM R07 exp343	1.74
Dorsomorphin 5μM R07 exp357	1.8
Bortezomib 0.005μM R00 exp6	1.82
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.86
Latrunculin-B 10μM R07 exp374	2.33

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of postsynaptic density protein 95 clustering
protein localization to microtubule
regulation of postsynaptic membrane organization
regulation of postsynaptic density organization
protein localization to microtubule cytoskeleton
dendritic shaft
protein localization to cytoskeleton
cytoplasmic microtubule organization
scaffold protein binding
PDZ domain binding
regulation of postsynapse organization
fibrillar center
dendritic spine
regulation of protein localization to membrane
regulation of synapse organization
regulation of synapse structure or activity
microtubule binding
postsynaptic density
protein-containing complex binding
neuronal cell body
dendrite
supramolecular fiber organization
microtubule cytoskeleton organization
regulation of cellular protein localization
cell junction
microtubule-based process
protein localization to organelle
nucleolus
regulation of cellular localization
regulation of protein localization
cytoskeleton organization
regulation of organelle organization
cellular protein localization
cellular macromolecule localization
establishment of protein localization