CRK
Gene Information
- Official Symbol: CRK
- Official Name: CRK proto-oncogene, adaptor protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 1398
- UniProt: P46108
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008].
- UniProt Summary: Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829}.
Pfam Domains GO Terms
Pfam Domains
| SH3 1 |
| SH2 |
| SH3 2 |
GO Terms
| cellular response to endothelin |
| response to cholecystokinin |
| response to endothelin |
| helper T cell diapedesis |
| cerebellar neuron development |
| protein phosphorylated amino acid binding |
| helper T cell extravasation |
| response to yeast |
| diapedesis |
| T cell extravasation |
| reelin-mediated signaling pathway |
| cellular response to insulin-like growth factor stimulus |
| regulation of Rac protein signal transduction |
| negative regulation of natural killer cell mediated cytotoxicity |
| negative regulation of natural killer cell mediated immunity |
| cellular response to nitric oxide |
| insulin-like growth factor receptor binding |
| negative regulation of leukocyte mediated cytotoxicity |
| response to hepatocyte growth factor |
| response to nitric oxide |
| cellular response to reactive nitrogen species |
| negative regulation of cell killing |
| protein tyrosine kinase binding |
| T cell migration |
| ephrin receptor binding |
| SH2 domain binding |
| positive regulation of smooth muscle cell migration |
| positive regulation of substrate adhesion-dependent cell spreading |
| negative regulation of lymphocyte mediated immunity |
| cellular extravasation |
| phosphotyrosine residue binding |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of T cell migration |
| regulation of natural killer cell mediated immunity |
| regulation of cell adhesion mediated by integrin |
| cellular response to nerve growth factor stimulus |
| response to fungus |
| negative regulation of leukocyte mediated immunity |
| response to bronchodilator |
| response to nerve growth factor |
| regulation of substrate adhesion-dependent cell spreading |
| activation of MAPKK activity |
| SH3/SH2 adaptor activity |
| protein self-association |
| negative regulation of innate immune response |
| scaffold protein binding |
| regulation of smooth muscle cell migration |
| regulation of lymphocyte migration |
| lymphocyte migration |
| vascular endothelial growth factor receptor signaling pathway |
| negative regulation of wound healing |
| cytoskeletal protein binding |
| regulation of leukocyte mediated cytotoxicity |
| central nervous system neuron development |
| hippocampus development |
| negative regulation of response to wounding |
| ephrin receptor signaling pathway |
| negative regulation of response to biotic stimulus |
| activation of GTPase activity |
| regulation of cell killing |
| cerebellum development |
| dendrite development |
| limbic system development |
| metencephalon development |
| cerebral cortex development |
| establishment of cell polarity |
| response to hydrogen peroxide |
| neuron migration |
| negative regulation of immune effector process |
| positive regulation of cell-substrate adhesion |
| SH3 domain binding |
| cellular response to reactive oxygen species |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| regulation of wound healing |
| Fc-gamma receptor signaling pathway |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| regulation of dendrite development |
| hindbrain development |
| regulation of cell shape |
| cellular response to transforming growth factor beta stimulus |
| positive regulation of cell morphogenesis involved in differentiation |
| response to transforming growth factor beta |
| regulation of response to wounding |
| pallium development |
| central nervous system neuron differentiation |
| response to reactive oxygen species |
| regulation of leukocyte migration |
| establishment or maintenance of cell polarity |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| cell chemotaxis |
| regulation of cell-substrate adhesion |
| negative regulation of multi-organism process |
| actin cytoskeleton |
| regulation of protein binding |
| cellular response to inorganic substance |
| membrane raft |
| cellular response to oxidative stress |
| Fc receptor signaling pathway |
| regulation of Ras protein signal transduction |
| telencephalon development |
| positive regulation of MAP kinase activity |
| cellular response to peptide hormone stimulus |
| negative regulation of cell motility |
| response to antibiotic |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| cellular response to peptide |
| activation of protein kinase activity |
| phagocytosis |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| negative regulation of response to external stimulus |
| regulation of binding |
| leukocyte migration |
| response to oxidative stress |
| forebrain development |
| regulation of actin filament-based process |
| response to peptide hormone |
| positive regulation of cell adhesion |
| cellular response to drug |
| positive regulation of GTPase activity |
| negative regulation of immune system process |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| regulation of immune effector process |
| response to peptide |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cell motility |
| regulation of response to biotic stimulus |
| response to growth factor |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| protein-containing complex |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| activation of immune response |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| brain development |
| regulation of MAPK cascade |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| head development |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of kinase activity |
| response to hormone |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | 2.06 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5309
- Expression level (log2 read counts): 5.48
Expression Distribution
CRK Expression in NALM6 Cells: 5.48
