CRLF3

Entrez Summary: This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012].
UniProt Summary: May play a role in the negative regulation of cell cycle progression. {ECO:0000269|PubMed:19427400}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of cell cycle arrest
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
regulation of cell cycle arrest
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
negative regulation of cell growth
negative regulation of growth
mitotic cell cycle phase transition
cell cycle phase transition
positive regulation of cell cycle process
positive regulation of cell cycle
regulation of cell growth
mitotic cell cycle process
regulation of growth
mitotic cell cycle
regulation of cell cycle process
cell cycle process
identical protein binding
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
cell cycle
DNA binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
positive regulation of RNA metabolic process
positive regulation of cell communication
positive regulation of signaling
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process