CROT

Entrez Summary: N/A
UniProt Summary: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester. {ECO:0000269|PubMed:10486279}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

carnitine O-octanoyltransferase activity
medium-chain fatty acid metabolic process
carnitine metabolic process
coenzyme A metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
amino-acid betaine metabolic process
peroxisomal matrix
fatty acid beta-oxidation
establishment of protein localization to peroxisome
protein targeting to peroxisome
protein localization to peroxisome
peroxisomal transport
fatty acid transport
fatty acid oxidation
lipid oxidation
peroxisome organization
fatty acid catabolic process
peroxisome
monocarboxylic acid catabolic process
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
monocarboxylic acid transport
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process
lipid modification
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid transport
organic acid transport
lipid transport
lipid catabolic process
purine ribonucleotide metabolic process
lipid localization
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process