CRP

Entrez Summary: The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009].
UniProt Summary: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

choline binding
complement component C1q binding
opsonization
virion binding
negative regulation of macrophage derived foam cell differentiation
low-density lipoprotein particle binding
negative regulation of lipid storage
positive regulation of superoxide anion generation
low-density lipoprotein particle receptor binding
regulation of superoxide anion generation
regulation of interleukin-8 secretion
regulation of macrophage derived foam cell differentiation
regulation of superoxide metabolic process
negative regulation of blood vessel diameter
acute-phase response
negative regulation of lipid localization
regulation of lipid storage
regulation of interleukin-8 production
acute inflammatory response
defense response to Gram-positive bacterium
positive regulation of reactive oxygen species metabolic process
regulation of lipid localization
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
complement activation, classical pathway
humoral immune response mediated by circulating immunoglobulin
vascular process in circulatory system
regulation of reactive oxygen species metabolic process
complement activation
regulation of cytokine secretion
immunoglobulin mediated immune response
B cell mediated immunity
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
phagocytosis
defense response to bacterium
humoral immune response
blood circulation
circulatory system process