CRTAM

Gene Information

Official Symbol: CRTAM
Official Name: cytotoxic and regulatory T cell molecule
Aliases and Previous Symbols: N/A
Entrez ID: 56253
UniProt: O95727
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11922
Expression level (log2 read counts): 1.84

Expression Distribution

V-set
C2-set 2
I-set

detection of tumor cell
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
activated T cell proliferation
positive regulation of natural killer cell mediated immune response to tumor cell
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
regulation of natural killer cell mediated immune response to tumor cell
response to tumor cell
positive regulation of immune response to tumor cell
positive regulation of response to tumor cell
regulation of immune response to tumor cell
regulation of response to tumor cell
T cell mediated cytotoxicity
detection of biotic stimulus
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
T cell proliferation
leukocyte mediated cytotoxicity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
lymphocyte proliferation
mononuclear cell proliferation
cell killing
leukocyte proliferation
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
positive regulation of cytokine secretion
regulation of lymphocyte mediated immunity
regulation of cytokine secretion
regulation of leukocyte mediated immunity
positive regulation of immune effector process
T cell activation
cell recognition
lymphocyte mediated immunity
positive regulation of protein secretion
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains