CSDE1 [The Human Chemical-Genetic Interaction Map Project]

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======= CSDE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSDE1
  * **<color #00a2e8>Official Name</color>**: cold shock domain containing E1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7812|7812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75534|O75534]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSDE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSDE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191510|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SUZ-C|
|CSD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear-transcribed mRNA catabolic process, no-go decay|
|CRD-mediated mRNA stability complex|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|nuclear-transcribed mRNA catabolic process|
|gonad development|
|mRNA catabolic process|
|development of primary sexual characteristics|
|RNA catabolic process|
|sex differentiation|
|nucleobase-containing compound catabolic process|
|reproductive structure development|
|reproductive system development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|developmental process involved in reproduction|
|mRNA metabolic process|
|cellular macromolecule catabolic process|
|Golgi apparatus|
|macromolecule catabolic process|
|RNA binding|
|reproductive process|
|reproduction|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.59|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.31|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.27|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.23|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.06|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.02|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.85|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.77|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.76|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.76|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.73|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.71|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.8|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.86|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.89|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.95|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.95|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.09|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.13|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.47|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.54|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:strap|STRAP]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7655
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSDE1 Expression in NALM6 Cells: 8.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>