CSDE1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK591 2.6μM R03 exp128	-2.59
Benzoate 10000μM R08 exp455	-2.31
BI-2536 0.02μM R03 exp96	-2.27
HMS-I2 5μM R06 exp287	-2.23
LJH685 50μM R08 exp433	-2.06
Trimetrexate 0.03μM R08 exp535	-2.02
B02 10μM R08 exp453	-1.85
Centrinone 0.5μM R07 exp343	-1.77
CCT251545 20μM R07 exp326	-1.76
CR131-b 0.005μM R08 exp474	-1.76
Thapsigargin 0.005μM R07 exp407	-1.73
Dorsomorphin 5μM R07 exp357	-1.71
Radicicol 0.16μM R05 exp242	1.8
Colchicine 0.009μM R05 exp215	1.86
Hydroxyurea 100μM R07 exp329	1.89
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.95
Pyridostatin 4μM R05 exp240	1.95
CoCl2 18μM R07 exp346	2.09
UM0125461 0.74μM R02 exp84	2.13
TRAIL 5ng/ml R00 exp35	2.47
MLN-4924 0.2μM R00 exp21	2.54
TRAIL 50ng/ml R00 exp36	2.77

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

SUZ-C
CSD

nuclear-transcribed mRNA catabolic process, no-go decay
CRD-mediated mRNA stability complex
male gonad development
development of primary male sexual characteristics
male sex differentiation
nuclear-transcribed mRNA catabolic process
gonad development
mRNA catabolic process
development of primary sexual characteristics
RNA catabolic process
sex differentiation
nucleobase-containing compound catabolic process
reproductive structure development
reproductive system development
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
developmental process involved in reproduction
mRNA metabolic process
cellular macromolecule catabolic process
Golgi apparatus
macromolecule catabolic process
RNA binding
reproductive process
reproduction
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process