CSH2

Gene Information

Official Symbol: CSH2
Official Name: chorionic somatomammotropin hormone 2
Aliases and Previous Symbols: N/A
Entrez ID: 1443
UniProt: P0DML3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. {ECO:0000269|PubMed:16546209}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 3883
Expression level (log2 read counts): -5.01

Expression Distribution

growth hormone receptor binding
growth hormone receptor signaling pathway
cellular response to growth hormone stimulus
response to growth hormone
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
hormone activity
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
vesicle
growth factor activity
positive regulation of peptidyl-tyrosine phosphorylation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of growth
cellular response to peptide hormone stimulus
cellular response to peptide
response to peptide hormone
response to peptide
response to nutrient levels
transmembrane receptor protein tyrosine kinase signaling pathway
response to extracellular stimulus
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
regulation of growth
enzyme linked receptor protein signaling pathway
response to hormone
response to organonitrogen compound
endoplasmic reticulum
positive regulation of protein phosphorylation
cellular response to oxygen-containing compound
positive regulation of phosphorylation
response to nitrogen compound
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation