CSNK2B [The Human Chemical-Genetic Interaction Map Project]

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======= CSNK2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSNK2B
  * **<color #00a2e8>Official Name</color>**: casein kinase 2 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1460|1460]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P67870|P67870]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSNK2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSNK2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/115441|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. {ECO:0000250, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CK II beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase CK2 complex|
|adiponectin-activated signaling pathway|
|positive regulation of activin receptor signaling pathway|
|protein kinase regulator activity|
|morphogenesis of an endothelium|
|endothelial tube morphogenesis|
|regulation of activin receptor signaling pathway|
|PcG protein complex|
|liver regeneration|
|ribonucleoprotein complex binding|
|negative regulation of blood vessel endothelial cell migration|
|phosphatidylcholine biosynthetic process|
|response to testosterone|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of endothelial cell migration|
|regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of epithelial cell migration|
|animal organ regeneration|
|phosphatidylcholine metabolic process|
|peptidyl-threonine phosphorylation|
|regulation of blood vessel endothelial cell migration|
|peptidyl-threonine modification|
|endothelium development|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nuclear matrix|
|chromatin|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|liver development|
|regulation of DNA binding|
|hepaticobiliary system development|
|regeneration|
|regulation of endothelial cell migration|
|macroautophagy|
|hormone-mediated signaling pathway|
|regulation of signal transduction by p53 class mediator|
|ammonium ion metabolic process|
|response to ketone|
|cilium|
|glycerophospholipid biosynthetic process|
|regulation of epithelial cell migration|
|glycerolipid biosynthetic process|
|protein folding|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein domain specific binding|
|phospholipid biosynthetic process|
|negative regulation of cell migration|
|process utilizing autophagic mechanism|
|autophagy|
|negative regulation of cell motility|
|epithelial tube morphogenesis|
|glycerophospholipid metabolic process|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|transcription factor binding|
|signaling receptor binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|protein serine/threonine kinase activity|
|phospholipid metabolic process|
|regulation of binding|
|glycerolipid metabolic process|
|chromatin binding|
|gland development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|tissue morphogenesis|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|tube development|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|leukocyte activation|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|immune effector process|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.77|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.7|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.78|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.91|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.1|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.11|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.15|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.17|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.18|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.23|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.23|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.25|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.4|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.49|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.77|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.84|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.84|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|3.2|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.32|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.52|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.63|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|4.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.621|
|[[:human genes:g:gfpt1|GFPT1]]|0.616|
|[[:human genes:r:rptor|RPTOR]]|0.611|
|[[:human genes:h:hars|HARS]]|0.6|
|[[:human genes:h:hspd1|HSPD1]]|0.595|
|[[:human genes:g:gmppb|GMPPB]]|0.593|
|[[:human genes:m:meaf6|MEAF6]]|0.585|
|[[:human genes:e:eny2|ENY2]]|0.579|
|[[:human genes:t:tti2|TTI2]]|0.569|
|[[:human genes:m:mtor|MTOR]]|0.568|
|[[:human genes:d:dpagt1|DPAGT1]]|0.561|
|[[:human genes:c:ccdc101|CCDC101]]|0.546|
|[[:human genes:t:thg1l|THG1L]]|0.543|
|[[:human genes:u:uap1|UAP1]]|0.542|
|[[:human genes:p:pmm2|PMM2]]|0.541|
|[[:human genes:r:rtcb|RTCB]]|0.538|
|[[:human genes:n:nxt1|NXT1]]|0.538|
|[[:human genes:b:bap1|BAP1]]|0.536|
|[[:human genes:n:nars|NARS]]|0.534|
|[[:human genes:a:apaf1|APAF1]]|0.534|
|[[:human genes:t:triap1|TRIAP1]]|0.532|
|[[:human genes:g:gnb1l|GNB1L]]|0.529|
|[[:human genes:o:otud5|OTUD5]]|0.527|
|[[:human genes:c:casp9|CASP9]]|0.525|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.523|
|[[:human genes:a:alg1|ALG1]]|0.515|
|[[:human genes:t:tti1|TTI1]]|0.513|
|[[:human genes:n:nupl2|NUPL2]]|0.499|
|[[:human genes:a:alg2|ALG2]]|0.497|
|[[:human genes:p:pam16|PAM16]]|0.496|
|[[:human genes:a:aars|AARS]]|0.495|
|[[:human genes:c:cbfb|CBFB]]|0.495|
|[[:human genes:e:eif4e|EIF4E]]|0.494|
|[[:human genes:e:eprs|EPRS]]|0.492|
|[[:human genes:h:hccs|HCCS]]|0.49|
|[[:human genes:n:nsd1|NSD1]]|0.489|
|[[:human genes:m:mars|MARS]]|0.489|
|[[:human genes:c:cct7|CCT7]]|0.489|
|[[:human genes:t:thoc6|THOC6]]|0.488|
|[[:human genes:a:alg5|ALG5]]|0.487|
|[[:human genes:m:mllt1|MLLT1]]|0.487|
|[[:human genes:w:wdr24|WDR24]]|0.487|
|[[:human genes:d:dohh|DOHH]]|0.485|
|[[:human genes:c:cycs|CYCS]]|0.482|
|[[:human genes:p:polr3h|POLR3H]]|0.481|
|[[:human genes:s:seh1l|SEH1L]]|0.481|
|[[:human genes:t:tsen54|TSEN54]]|0.477|
|[[:human genes:a:atp5j|ATP5J]]|0.474|
|[[:human genes:t:telo2|TELO2]]|0.474|
|[[:human genes:u:ube2k|UBE2K]]|0.473|
|[[:human genes:t:tle4|TLE4]]|0.473|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.471|
|[[:human genes:m:med16|MED16]]|0.471|
|[[:human genes:m:mapk14|MAPK14]]|0.469|
|[[:human genes:s:spcs2|SPCS2]]|0.467|
|[[:human genes:d:diablo|DIABLO]]|0.466|
|[[:human genes:e:exoc4|EXOC4]]|0.465|
|[[:human genes:s:slc35b1|SLC35B1]]|0.462|
|[[:human genes:a:alg14|ALG14]]|0.461|
|[[:human genes:s:srp72|SRP72]]|0.461|
|[[:human genes:u:uba3|UBA3]]|0.459|
|[[:human genes:m:med23|MED23]]|0.457|
|[[:human genes:p:plaa|PLAA]]|0.454|
|[[:human genes:p:polr3b|POLR3B]]|0.453|
|[[:human genes:n:nae1|NAE1]]|0.452|
|[[:human genes:t:tsen34|TSEN34]]|0.452|
|[[:human genes:t:trmt5|TRMT5]]|0.452|
|[[:human genes:u:uxt|UXT]]|0.448|
|[[:human genes:c:cars|CARS]]|0.448|
|[[:human genes:p:pisd|PISD]]|0.443|
|[[:human genes:v:vrk1|VRK1]]|0.442|
|[[:human genes:b:bak1|BAK1]]|0.442|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.441|
|[[:human genes:d:dnajc3|DNAJC3]]|0.44|
|[[:human genes:u:uhrf1|UHRF1]]|0.439|
|[[:human genes:s:srp68|SRP68]]|0.437|
|[[:human genes:s:sec61g|SEC61G]]|0.437|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.435|
|[[:human genes:u:ubr5|UBR5]]|0.434|
|[[:human genes:d:dad1|DAD1]]|0.434|
|[[:human genes:t:trnt1|TRNT1]]|0.433|
|[[:human genes:c:cep350|CEP350]]|0.433|
|[[:human genes:y:yars|YARS]]|0.432|
|[[:human genes:e:eno1|ENO1]]|0.432|
|[[:human genes:t:tbca|TBCA]]|0.432|
|[[:human genes:t:tamm41|TAMM41]]|0.43|
|[[:human genes:v:vhl|VHL]]|0.427|
|[[:human genes:o:osgep|OSGEP]]|0.427|
|[[:human genes:t:tbcd|TBCD]]|0.426|
|[[:human genes:r:rpn1|RPN1]]|0.426|
|[[:human genes:o:oraov1|ORAOV1]]|0.425|
|[[:human genes:n:nsmce2|NSMCE2]]|0.423|
|[[:human genes:s:srp14|SRP14]]|0.422|
|[[:human genes:d:dpf2|DPF2]]|0.421|
|[[:human genes:r:rpe|RPE]]|0.421|
|[[:human genes:a:adsl|ADSL]]|0.421|
|[[:human genes:z:znf608|ZNF608]]|0.42|
|[[:human genes:t:thoc3|THOC3]]|0.42|
|[[:human genes:s:smarcd1|SMARCD1]]|0.419|
|[[:human genes:f:fbxo11|FBXO11]]|0.417|
|[[:human genes:v:vmp1|VMP1]]|0.417|
|[[:human genes:h:hhex|HHEX]]|0.417|
|[[:human genes:r:rpp21|RPP21]]|0.416|
|[[:human genes:p:ppa2|PPA2]]|0.416|
|[[:human genes:t:trip12|TRIP12]]|0.415|
|[[:human genes:t:tgs1|TGS1]]|0.415|
|[[:human genes:m:march5|MARCH5]]|0.413|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.413|
|[[:human genes:n:nup50|NUP50]]|0.413|
|[[:human genes:a:atxn10|ATXN10]]|0.412|
|[[:human genes:c:crls1|CRLS1]]|0.412|
|[[:human genes:n:nsmce1|NSMCE1]]|0.407|
|[[:human genes:w:wars|WARS]]|0.407|
|[[:human genes:p:pelo|PELO]]|0.405|
|[[:human genes:h:hmgb2|HMGB2]]|0.405|
|[[:human genes:m:med4|MED4]]|0.404|
|[[:human genes:w:wdr59|WDR59]]|0.402|
|[[:human genes:t:tbp|TBP]]|0.401|
|[[:human genes:s:spcs3|SPCS3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 655/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|20/28|
|bone|22/25|
|breast|32/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|16/21|
|liver|17/20|
|lung|68/75|
|lymphocyte|13/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|6/7|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 266
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSNK2B Expression in NALM6 Cells: 6.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>